Phytother Res 2010,
PMID: 19455572
Park, Sun Hong; Kang, Jong Soon; Yoon, Yeo Dae; Lee, Kiho; Kim, Kang-Jeon; Lee, Ki Hoon; Lee, Chang Woo; Moon, Eun-Yi; Han, Sang-Bae; Kim, Bong Hee; Kim, Hwan Mook; Park, Song-Kyu
Glabridin, a flavonoid present in licorice root, is known to have antiinflammatory and cardiovascular protective activities. The present study reports an inhibitory effect of glabridin on microglial activation. Glabridin dose-dependently attenuated lipopolysaccharide (LPS)-induced production of inflammatory mediators, including nitric oxide, tumor necrosis factor-alpha and interleukin-1beta, in BV-2 cells, a murine microglia cell line. Moreover, mRNA expression of these inflammatory mediators was also suppressed by glabridin in LPS-stimulated BV-2 cells. Further study demonstrated that glabridin inhibited LPS-induced DNA binding activity of NF-kappaB and AP-1 in BV-2 cells. Collectively, the results presented in this report demonstrate that glabridin inhibits the production of inflammatory mediators in BV-2 cells and this is mediated, at least in part, by blocking NF-kappaB and AP-1 activation. The results suggest that glabridin might be a potential therapeutic agent for the treatment of neuroinflammatory and neurodegenerative diseases.
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Text Mining Data
AP-1 → LPS: "
Further study demonstrated that glabridin inhibited
LPS induced DNA binding activity of NF-kappaB and
AP-1 in BV-2 cells
"
NF-kappaB → LPS: "
Further study demonstrated that glabridin inhibited LPS induced DNA binding activity of NF-kappaB and AP-1 in BV-2 cells
"
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