Cancer Cell 2009,
PMID: 19573813
Zhang, Xiang H-F; Wang, Qiongqing; Gerald, William; Hudis, Clifford A; Norton, Larry; Smid, Marcel; Foekens, John A; Massagué, Joan
Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We report that a gene expression signature of Src activation is associated with late-onset bone metastasis in breast cancer. This link is independent of hormone receptor status or breast cancer subtype. In breast cancer cells, Src is dispensable for homing to the bones or lungs but is critical for the survival and outgrowth of these cells in the bone marrow. Src mediates AKT regulation and cancer cell survival responses to CXCL12 and TNF-related apoptosis-inducing ligand (TRAIL), factors that are distinctively expressed in the bone metastasis microenvironment. Breast cancer cells that lodge in the bone marrow succumb in this environment when deprived of Src activity.
Diseases/Pathways annotated by Medline MESH: Bone Neoplasms, Breast Neoplasms, Neoplasm Metastasis
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Text Mining Data
AKT → Src: "
Src mediates
AKT regulation and cancer cell survival responses to CXCL12 and TNF related apoptosis inducing ligand ( TRAIL ), factors that are distinctively expressed in the bone metastasis microenvironment
"
Manually curated Databases
No curated data.