Gene interactions and pathways from curated databases and text-mining
Molecular systems biology 2009, PMID: 19953087

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.

Persaud, Avinash; Alberts, Philipp; Amsen, Eva M; Xiong, Xuejian; Wasmuth, James; Saadon, Zachary; Fladd, Chris; Parkinson, John; Rotin, Daniela

Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2-4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close relatives: Nedd4 (Nedd4-1) and Nedd4L (Nedd4-2), but their global substrate recognition or differences in substrate specificity are unknown. We performed in vitro ubiquitylation and binding assays of human Nedd4-1 and Nedd4-2, and rat-Nedd4-1, using protein microarrays spotted with approximately 8200 human proteins. Top hits (substrates) for the ubiquitylation and binding assays mostly contain PY motifs. Although several substrates were recognized by both Nedd4-1 and Nedd4-2, others were specific to only one, with several Tyr kinases preferred by Nedd4-1 and some ion channels by Nedd4-2; this was subsequently validated in vivo. Accordingly, Nedd4-1 knockdown or knockout in cells led to sustained signalling via some of its substrate Tyr kinases (e.g. FGFR), suggesting Nedd4-1 suppresses their signalling. These results demonstrate the feasibility of identifying substrates and deciphering substrate specificity of mammalian E3 ligases.

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Text Mining Data

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Manually curated Databases

  • IRef Biogrid Interaction: NEDD4 — RPAP3 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FGFR1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — NTRK1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — NTRK1 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — SMAD3 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TAF1B — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: AICDA — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — TSTA3 (direct interaction, pull down)
  • IRef Biogrid Interaction: EFEMP2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DAPK3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: KCNAB3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4L — ACVR1B (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4L — ACVR1B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4 — MAP2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MRPL19 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: ABL2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: HMCES — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: PRKX — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: SRMS — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NDFIP2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: STK4 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: YY1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: YY1 — NEDD4L (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRIM44 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CDK3 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: TRIM52 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TRIM52 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FKBP3 (direct interaction, pull down)
  • IRef Biogrid Interaction: VDAC2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: VDAC2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: TGFB1I1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: PRR16 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: CYP26B1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: MAP3K2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: SULF1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FLT4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — CDK5 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — CDK5 (direct interaction, pull down)
  • IRef Biogrid Interaction: WBP2 — NEDD4L (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4 — CLIC2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: BMPR1A — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — SYT1 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — CALCOCO1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DDX54 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DDX54 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — TOM1L2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — RFT1 (direct interaction, pull down)
  • IRef Biogrid Interaction: UBAC1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: UBAC1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NHP2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — AKT3 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — AKT3 (direct interaction, pull down)
  • IRef Biogrid Interaction: TRIM41 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: MRPL19 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: TMEM55A — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: CUEDC1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CUEDC1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: SCD — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: RPS6KB2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: H1F0 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — SGK2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — AURKC (direct interaction, pull down)
  • IRef Biogrid Interaction: ZADH2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: CLIC2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CLIC2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: FKBP3 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: FKBP3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TCEAL2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: CUEDC1 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CUEDC1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: PRR16 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — RTF1 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — RTF1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — RTF1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4 — RPS6KB1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — KCNAB1 (direct interaction, pull down)
  • IRef Biogrid Interaction: APEX2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: KCNB1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: KCNB1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: RPS6KA4 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: MAP2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: KCNAB1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: KCNAB1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: PRKX — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — TOM1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — CAMKK2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — MAPKAPK3 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RANBP10 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ANXA9 — NEDD4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4 — TBC1D7 (direct interaction, pull down)
  • IRef Biogrid Interaction: MINK1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — CAMK4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — ASPSCR1 (direct interaction, pull down)
  • IRef Biogrid Interaction: WIBG — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: PLK1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — IRS1 (direct interaction, pull down)
  • IRef Biogrid Interaction: RNF7 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — TCEANC (direct interaction, pull down)
  • IRef Biogrid Interaction: WIBG — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RPL30 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RPL30 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FES (direct interaction, pull down)
  • IRef Biogrid Interaction: NTRK1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: MAP3K5 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — CLK3 (direct interaction, pull down)
  • IRef Biogrid Interaction: YY1 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: YY1 — NEDD4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4L — HGS (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — ERMN (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — RBCK1 (direct interaction, pull down)
  • IRef Biogrid Interaction: EGFR — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: EGFR — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — C11orf63 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NSRP1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NSRP1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — RNF7 (direct interaction, pull down)
  • IRef Biogrid Interaction: CAMK1D — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DDX54 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DDX54 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — RAD51AP1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ROBO3 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — PLK2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: MERTK — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: C7orf50 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: MAP3K5 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: BRAF — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CACNB1 — NEDD4L (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CACNB1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: CACNB1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TBC1D7 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: EBAG9 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: MAGEB1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: UBE2M — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: UBE2D2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: MOB3A — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: SRMS — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: RASL10B — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: GRK7 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: SPANXN3 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ANKRD13D — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: FGF21 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: TAF1B — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FYN (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — FYN (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FGF12 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — MAP4K5 (direct interaction, pull down)
  • IRef Biogrid Interaction: STK40 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — UBOX5 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — UBOX5 (direct interaction, pull down)
  • IRef Biogrid Interaction: SGK2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ZC3HAV1L — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — KIAA1598 (direct interaction, pull down)
  • IRef Biogrid Interaction: RASL11B — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: BMPR1A — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: BMPR1A — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — ABL2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — MAP3K2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — MAP3K2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — LUC7L2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: AKT1 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: FGF12 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: MARK4 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ZAK — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — SEPT9 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4L — SENP2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — STK24 (direct interaction, pull down)
  • IRef Biogrid Interaction: PARP16 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — GRK4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — RPS6KA3 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RANBP10 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RANBP10 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: RASL11B — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — STK25 (direct interaction, pull down)
  • IRef Biogrid Interaction: PKN2 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: AURKC — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DYRK3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4L — SERPINF1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: CDK5 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NSRP1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: DECR2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: SP140L — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: MAPKAPK3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TARBP2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: RASGEF1A — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: DMTN — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TBK1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — MARK2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — CAMK1D (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — CAMK1D (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: AKT3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RAF1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: PDGFRB — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: PDGFRB — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — NHP2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FLT1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — FLT1 (direct interaction, pull down)
  • IRef Biogrid Interaction: PRKG2 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: MOB3A — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: MARK2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ADAP2 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ADAP2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — BAIAP2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: TCP11L1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — GBA (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — MAP3K3 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — MAP3K3 (direct interaction, pull down)
  • IRef Biogrid Interaction: UBC — CACNB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SIVA1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: SIVA1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: UBC — RTF1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ANXA9 — UBC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4 — STK31 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: KIFC3 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: ABL1 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: ZDHHC3 — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — MST4 (direct interaction, pull down)
  • IRef Biogrid Interaction: PRRG1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: TMA16 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: WEE1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — DYRK4 (direct interaction, pull down)
  • IRef Biogrid Interaction: SLC23A2 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: SYK — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — AMPD2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NUDT16L1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: UBC — ACVR1B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRRG1 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — FGFR2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — FGFR2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — KCNAB2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4L — MAP3K3 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — ABL1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — ABL1 (direct interaction, pull down)
  • IRef Biogrid Interaction: SPAG8 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — CDK5R1 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — EPHA5 (direct interaction, pull down)
  • IRef Biogrid Interaction: YY1 — UBC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KCNAB2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: IFRD2 — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: SAAL1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: STAC — NEDD4L (direct interaction, pull down)
  • IRef Biogrid Interaction: BBX — NEDD4L (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — KIFC3 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — SAMSN1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: YES1 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: TEAD2 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — LAPTM5 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: WBP2 — UBC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NEDD4 — SGK1 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: RNF11 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: WBP2 — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: WBP2 — NEDD4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: WBP2 — NEDD4 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — NDFIP2 (direct interaction, pull down)
  • IRef Biogrid Interaction: NEDD4 — NDFIP2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: SCNN1B — NEDD4 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: NEDD4 — UBE2D2 (direct interaction, pull down)
In total, 217 gene pairs are associated to this article in curated databases