Gene interactions and pathways from curated databases and text-mining
PloS one 2010, PMID: 20098747

Expanding the substantial interactome of NEMO using protein microarrays.

Fenner, Beau J; Scannell, Michael; Prehn, Jochen H M

Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals transmitted from upstream sensors to the downstream NF-kappaB transcription factor and subsequent gene activation. The position of NEMO within this pathway makes it an attractive target from which to search for new proteins that link NF-kappaB signaling to additional pathways and upstream effectors. In this work, we have used protein microarrays to identify novel NEMO interactors. A total of 112 protein interactors were identified, with the most statistically significant hit being the canonical NEMO interactor IKKbeta, with IKKalpha also being identified. Of the novel interactors, more than 30% were kinases, while at least 25% were involved in signal transduction. Binding of NEMO to several interactors, including CALB1, CDK2, SAG, SENP2 and SYT1, was confirmed using GST pulldown assays and coimmunoprecipitation, validating the initial screening approach. Overexpression of CALB1, CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB, while SYT1 overexpression repressed TNFalpha-dependent NF-kappaB transcriptional activation in human embryonic kidney cells. Corresponding with this finding, RNA silencing of CDK2, SAG and SENP2 reduced NF-kappaB transcriptional activation, supporting a positive role for these proteins in the NF-kappaB pathway. The identification of a host of new NEMO interactors opens up new research opportunities to improve understanding of this essential cell signaling pathway.

Document information provided by NCBI PubMed

Text Mining Data

NF-kappaB ⊣ SYT1: " Overexpression of CALB1, CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB, while SYT1 overexpression repressed TNFalpha dependent NF-kappaB transcriptional activation in human embryonic kidney cells "

NF-kappaB → TNFalpha: " Overexpression of CALB1, CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB, while SYT1 overexpression repressed TNFalpha dependent NF-kappaB transcriptional activation in human embryonic kidney cells "

NF-kappaB → SAG: " Corresponding with this finding, RNA silencing of CDK2, SAG and SENP2 reduced NF-kappaB transcriptional activation, supporting a positive role for these proteins in the NF-kappaB pathway "

NF-kappaB → CDK2: " Corresponding with this finding, RNA silencing of CDK2 , SAG and SENP2 reduced NF-kappaB transcriptional activation, supporting a positive role for these proteins in the NF-kappaB pathway "

NF-kappaB → SENP2: " Corresponding with this finding, RNA silencing of CDK2, SAG and SENP2 reduced NF-kappaB transcriptional activation, supporting a positive role for these proteins in the NF-kappaB pathway "

Manually curated Databases

  • IRef Biogrid Interaction: IKBKB — IKBKG (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IKBKB — IKBKG (direct interaction, two hybrid)
  • IRef Biogrid Interaction: IKBKB — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RPL41 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ALK — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RNF7 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RNF7 — IKBKG (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RNF7 — IKBKG (direct interaction, two hybrid)
  • IRef Biogrid Interaction: PIM2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: MYL5 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: C19orf57 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: STK25 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ODAM — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: MERTK — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ARL6IP4 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: WDR5 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PDCL — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: LZIC — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ADAP2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TCEANC — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PRKD3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PHF7 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TYRO3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: APRT — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: MZT2A — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: DAPK1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ITK — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PNMAL1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TRIM41 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TSLP — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RBCK1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: MCM10 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: LUC7L2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: VAMP3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TPT1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: KIAA1598 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: JAK2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RBM8A — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PSMA3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: H1F0 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: EPHA4 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: JAK3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: GADD45GIP1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: DNAJC8 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: AMMECR1L — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: GRK4 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: FRMD8 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: NTMT1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RBM34 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: LCK — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: GADD45G — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: MAP3K2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TBC1D7 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: NECAB3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: AVPI1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: IKBKG — SENP2 (direct interaction, pull down)
  • IRef Biogrid Interaction: IKBKG — SENP2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IKBKG — SENP2 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: MLLT6 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TTYH2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: NHP2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: SEPT9 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: DDX19B — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: NAP1L5 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PRKCB — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TCP11L1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RPS12 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: SRPK1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: HPCAL1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: SGK1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: LGALS2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: IKBKG — KRT8 (direct interaction, pull down)
  • IRef Biogrid Interaction: PLEKHJ1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CDK2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CDK2 — IKBKG (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CDK2 — IKBKG (direct interaction, two hybrid)
  • IRef Biogrid Interaction: TMA16 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ACBD6 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PCK1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: NRBF2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TCP10L — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CNOT7 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ROS1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ARGLU1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: SCLT1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RET — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: AKT1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CETN3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RPS6KB2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: LMCD1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CALB1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CALB1 — IKBKG (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CALB1 — IKBKG (direct interaction, two hybrid)
  • IRef Biogrid Interaction: GNGT1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: FLT3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: RPAP3 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: PFDN5 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: GYG2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: EIF1AX — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CUEDC1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: GEMIN2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CPNE2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: SYT1 — IKBKG (direct interaction, two hybrid)
  • IRef Biogrid Interaction: SYT1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: SYT1 — IKBKG (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HBZ — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TEC — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: NRARP — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TCP11 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: FGR — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ARPP19 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: ROR2 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TEK — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: FLT4 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: C19orf12 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: LPXN — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: MCM7 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: TBK1 — IKBKG (direct interaction, pull down)
  • IRef Biogrid Interaction: CHUK — IKBKG (direct interaction, pull down)
  • IRef Innatedb Interaction: IKBKG — IKBKB (unknown, -)
  • IRef Innatedb Interaction: IKBKG — ALK (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MYL5 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — C19orf57 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — STK25 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — ODAM (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MERTK (unknown, -)
  • IRef Innatedb Interaction: IKBKG — ARL6IP4 (unknown, -)
  • IRef Innatedb Interaction: LZIC — IKBKG (unknown, -)
  • IRef Innatedb Interaction: ADAP2 — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — TCEANC (unknown, -)
  • IRef Innatedb Interaction: IKBKG — PRKD3 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — APRT (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MZT2A (unknown, -)
  • IRef Innatedb Interaction: IKBKG — DAPK1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — ITK (unknown, -)
  • IRef Innatedb Interaction: IKBKG — RBCK1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MCM10 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — LUC7L2 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — KIAA1598 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — JAK2 (unknown, -)
  • IRef Innatedb Interaction: H1F0 — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — EPHA4 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — JAK3 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — GADD45GIP1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — DNAJC8 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — AMMECR1L (unknown, -)
  • IRef Innatedb Interaction: IKBKG — GRK4 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — FRMD8 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — NTMT1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — RBM34 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — LCK (unknown, -)
  • IRef Innatedb Interaction: GADD45G — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MAP3K2 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — NECAB3 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — AVPI1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MLLT6 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — NHP2 (unknown, -)
  • IRef Innatedb Interaction: DDX19B — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — HPCAL1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — LGALS2 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — KRT8 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — PLEKHJ1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — CDK2 (unknown, -)
  • IRef Innatedb Interaction: ACBD6 — IKBKG (unknown, -)
  • IRef Innatedb Interaction: CNOT7 — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — ARGLU1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — AKT1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — CETN3 (unknown, -)
  • IRef Innatedb Interaction: RPS6KB2 — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — LMCD1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — CALB1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — GNGT1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — FLT3 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — PFDN5 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — GYG2 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — EIF1AX (unknown, -)
  • IRef Innatedb Interaction: IKBKG — CUEDC1 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — GEMIN2 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — CPNE2 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — HBZ (unknown, -)
  • IRef Innatedb Interaction: IKBKG — TCP11 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — FGR (unknown, -)
  • IRef Innatedb Interaction: IKBKG — ARPP19 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — C19orf12 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — LPXN (unknown, -)
  • IRef Innatedb Interaction: IKBKG — KIR3DX1 (unknown, -)
  • IRef Innatedb Interaction: SAG — IKBKG (unknown, -)
  • IRef Innatedb Interaction: IKBKG — MCM7 (unknown, -)
  • IRef Innatedb Interaction: IKBKG — CHUK (unknown, -)
  • IRef Intact Interaction: IKBKG — IKBKB (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: IKBKG — IKBKB (physical association, two hybrid)
  • IRef Intact Interaction: IKBKG — IKBKB (physical association, pull down)
  • IRef Intact Interaction: IKBKG — IKBKB (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RPL41 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RNF7 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RNF7 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: IKBKG — RNF7 (physical association, two hybrid)
  • IRef Intact Interaction: IKBKG — RNF7 (physical association, pull down)
  • IRef Intact Interaction: PIM2 — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — MYL5 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — C19orf57 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — STK25 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — ODAM (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — ARL6IP4 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — WDR5 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — PDCL (direct interaction, protein array)
  • IRef Intact Interaction: LZIC — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: ADAP2 — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TCEANC (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — PRKD3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — PHF7 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TYRO3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — MZT2A (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — DAPK1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — ITK (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — PNMAL1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TRIM41 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TSLP (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RBCK1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — MCM10 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — LUC7L2 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TPT1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — KIAA1598 (direct interaction, protein array)
  • IRef Intact Interaction: RBM8A — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: PSMA3 — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: H1F0 — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — EPHA4 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — JAK3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — GADD45GIP1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — AMMECR1L (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — GRK4 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — FRMD8 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — NTMT1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RBM34 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — LCK (direct interaction, protein array)
  • IRef Intact Interaction: GADD45G — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TBC1D7 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — NECAB3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — SENP2 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: IKBKG — SENP2 (physical association, two hybrid)
  • IRef Intact Interaction: IKBKG — SENP2 (physical association, pull down)
  • IRef Intact Interaction: IKBKG — TTYH2 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — NHP2 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — SEPT9 (direct interaction, protein array)
  • IRef Intact Interaction: DDX19B — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — NAP1L5 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — PRKCB (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TCP11L1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — SRPK1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — SGK1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — KRT8 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — PLEKHJ1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — CDK2 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: IKBKG — CDK2 (physical association, two hybrid)
  • IRef Intact Interaction: IKBKG — CDK2 (physical association, pull down)
  • IRef Intact Interaction: IKBKG — CDK2 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TMA16 (direct interaction, protein array)
  • IRef Intact Interaction: ACBD6 — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — NRBF2 (direct interaction, protein array)
  • IRef Intact Interaction: TCP10L — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: CNOT7 — IKBKG (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — ARGLU1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — SCLT1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RET (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — AKT1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — CETN3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — LMCD1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — CALB1 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: IKBKG — CALB1 (physical association, two hybrid)
  • IRef Intact Interaction: IKBKG — CALB1 (physical association, pull down)
  • IRef Intact Interaction: IKBKG — FLT3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — RPAP3 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — GYG2 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — CUEDC1 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — GEMIN2 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — SYT1 (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: IKBKG — SYT1 (physical association, two hybrid)
  • IRef Intact Interaction: IKBKG — SYT1 (physical association, pull down)
  • IRef Intact Interaction: IKBKG — NRARP (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TCP11 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — ARPP19 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TEK (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — FLT4 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — C19orf12 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — LPXN (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — MCM7 (direct interaction, protein array)
  • IRef Intact Interaction: IKBKG — TBK1 (direct interaction, protein array)
In total, 109 gene pairs are associated to this article in curated databases