Gene interactions and pathways from curated databases and text-mining
Biochem J 2011, PMID: 21711248

Fibroblast growth factors and their receptors in cancer.

Wesche, Jørgen; Haglund, Kaisa; Haugsten, Ellen Margrethe

FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other hand, has been associated with many developmental syndromes, and with human cancer. In cancer, FGFRs have been found to become overactivated by several mechanisms, including gene amplification, chromosomal translocation and mutations. FGFR alterations are detected in a variety of human cancers, such as breast, bladder, prostate, endometrial and lung cancers, as well as haematological malignancies. Accumulating evidence indicates that FGFs and FGFRs may act in an oncogenic fashion to promote multiple steps of cancer progression by inducing mitogenic and survival signals, as well as promoting epithelial-mesenchymal transition, invasion and tumour angiogenesis. Therapeutic strategies targeting FGFs and FGFRs in human cancer are therefore currently being explored. In the present review we will give an overview of FGF signalling, the main FGFR alterations found in human cancer to date, how they may contribute to specific cancer types and strategies for therapeutic intervention.

Diseases/Pathways annotated by Medline MESH: Breast Neoplasms, Lung Neoplasms, Multiple Myeloma, Myeloproliferative Disorders, Neoplasms, Prostatic Neoplasms, Rhabdomyosarcoma, Urinary Bladder Neoplasms
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: FGF17 → FGF22 (reaction)
  • Reactome Reaction: FGF16 → FGF22 (reaction)
  • Reactome Reaction: FGFR1 → NRAS (reaction)
  • Reactome Reaction: FGF4 → FGF16 (reaction)
  • Reactome Reaction: FGF2 → FGF8 (reaction)
  • Reactome Reaction: FGF16 → FGF20 (reaction)
  • Reactome Reaction: FGF7 → FGF22 (reaction)
  • Reactome Reaction: FGF1 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF1 → PIK3CA (reaction)
  • Reactome Reaction: FGF7 → NRAS (reaction)
  • Reactome Reaction: GRB2 → KRAS (reaction)
  • Reactome Reaction: FGF17 → GRB2 (reaction)
  • Reactome Reaction: FGF23 → FGFR4 (reaction)
  • Reactome Reaction: FGFR3 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF9 (reaction)
  • Reactome Reaction: FGFR1 → FGFR4 (reaction)
  • Reactome Reaction: FGF10 → NRAS (reaction)
  • Reactome Reaction: FGF17 → FGF17 (reaction)
  • Reactome Reaction: FRS2 → FRS2 (reaction)
  • Reactome Reaction: FGF3 → FGF17 (reaction)
  • Reactome Reaction: FGFR3 → SOS1 (indirect_complex)
  • Reactome Reaction: FGFR3 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → FGF10 (reaction)
  • Reactome Reaction: FGF5 → GRB2 (reaction)
  • Reactome Reaction: FGF3 → HRAS (reaction)
  • Reactome Reaction: FGFR4 → FGFR3 (reaction)
  • Reactome Reaction: FGF16 → PIK3CA (reaction)
  • Reactome Reaction: FGF3 → GRB2 (reaction)
  • Reactome Reaction: FGF18 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF22 → FRS2 (reaction)
  • Reactome Reaction: FGF5 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF8 → HRAS (reaction)
  • Reactome Reaction: FGF22 → KRAS (reaction)
  • Reactome Reaction: FGF1 → KRAS (reaction)
  • Reactome Reaction: FGF2 → FGF22 (reaction)
  • Reactome Reaction: FGF9 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF5 → PIK3CA (reaction)
  • Reactome Reaction: FGF3 → FGF10 (reaction)
  • Reactome Reaction: FGFR4 → HRAS (reaction)
  • Reactome Reaction: FGFR4 → FRS2 (reaction)
  • Reactome Reaction: FGF16 → HRAS (reaction)
  • Reactome Reaction: FGF18 → FGF23 (reaction)
  • Reactome Reaction: FGF4 → FGF7 (reaction)
  • Reactome Reaction: KRAS → FGFR3 (reaction)
  • Reactome Reaction: FGF7 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF5 → HRAS (reaction)
  • Reactome Reaction: FGF1 → FGFR2 (reaction)
  • Reactome Reaction: FGF8 → NRAS (reaction)
  • Reactome Reaction: FGF10 → FGFR3 (reaction)
  • Reactome Reaction: FGF4 → FGF23 (reaction)
  • Reactome Reaction: FGFR1 → HRAS (reaction)
  • Reactome Reaction: FGF6 → KRAS (reaction)
  • Reactome Reaction: FGF7 → FGF23 (reaction)
  • Reactome Reaction: FGFR1 → SOS1 (reaction)
  • Reactome Reaction: KRAS → FGFR2 (reaction)
  • Reactome Reaction: FGF8 → FGF20 (reaction)
  • Reactome Reaction: FGF4 → FGF4 (reaction)
  • Reactome Reaction: FGF8 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF23 → GRB2 (reaction)
  • Reactome Reaction: FGF16 → SOS1 (reaction)
  • Reactome Reaction: FGF9 → FRS2 (reaction)
  • Reactome Reaction: FGF3 → FGF7 (reaction)
  • Reactome Reaction: FGF18 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF18 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF23 → FGFR2 (reaction)
  • Reactome Reaction: FGFR4 → FGFR2 (reaction)
  • Reactome Reaction: FGF23 → SOS1 (indirect_complex)
  • Reactome Reaction: FGFR2 → HRAS (reaction)
  • Reactome Reaction: FGFR2 → PIK3CA (reaction)
  • Reactome Reaction: FGF1 → FGF2 (reaction)
  • Reactome Reaction: FGF5 → FGF8 (reaction)
  • Reactome Reaction: FGF17 → FGFR1 (reaction)
  • Reactome Reaction: FGFR4 → FGFR4 (reaction)
  • Reactome Reaction: FGF10 → SOS1 (indirect_complex)
  • Reactome Reaction: FRS2 → FGFR3 (reaction)
  • Reactome Reaction: FGF3 → FGF9 (reaction)
  • Reactome Reaction: FGFR3 → FGFR4 (reaction)
  • Reactome Reaction: FGF8 → GRB2 (reaction)
  • Reactome Reaction: FGF1 → FRS2 (reaction)
  • Reactome Reaction: FGF22 → HRAS (reaction)
  • Reactome Reaction: FGF1 → SOS1 (reaction)
  • Reactome Reaction: FGF20 → FGF23 (reaction)
  • Reactome Reaction: FGF23 → NRAS (reaction)
  • Reactome Reaction: FGF5 → FGF6 (reaction)
  • Reactome Reaction: FGF10 → FGF17 (reaction)
  • Reactome Reaction: FGF17 → FGF18 (reaction)
  • Reactome Reaction: FGF17 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF3 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF8 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF5 → FRS2 (reaction)
  • Reactome Reaction: FGF20 → FGF20 (reaction)
  • Reactome Reaction: FGF1 → FGF1 (reaction)
  • Reactome Reaction: FGF17 → FGFR2 (reaction)
  • Reactome Reaction: FGF6 → FGF8 (reaction)
  • Reactome Reaction: FGF10 → SOS1 (reaction)
  • Reactome Reaction: FGFR2 → FRS2 (reaction)
  • Reactome Reaction: FGFR4 → FGFR1 (reaction)
  • Reactome Reaction: FGF17 → HRAS (reaction)
  • Reactome Reaction: FGF18 → FGFR2 (reaction)
  • Reactome Reaction: FGF5 → FGF5 (reaction)
  • Reactome Reaction: FGF10 → FGF10 (reaction)
  • Reactome Reaction: FGF18 → KRAS (reaction)
  • Reactome Reaction: FGFR2 → SOS1 (reaction)
  • Reactome Reaction: FGF10 → FGF16 (reaction)
  • Reactome Reaction: FGF4 → FGF17 (reaction)
  • Reactome Reaction: FGF5 → KRAS (reaction)
  • Reactome Reaction: FGF7 → FGF18 (reaction)
  • Reactome Reaction: FGF6 → FGF22 (reaction)
  • Reactome Reaction: FGF9 → FGFR4 (reaction)
  • Reactome Reaction: FGF17 → FRS2 (reaction)
  • Reactome Reaction: FGF4 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF16 → FGF16 (reaction)
  • Reactome Reaction: FGF5 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF20 → FGFR1 (reaction)
  • Reactome Reaction: FGFR3 → KRAS (reaction)
  • Reactome Reaction: FGF4 → FGF18 (reaction)
  • Reactome Reaction: FGF16 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF1 → HRAS (reaction)
  • Reactome Reaction: FGF6 → FGFR4 (reaction)
  • Reactome Reaction: FGF2 → FGFR1 (reaction)
  • Reactome Reaction: FGF2 → FGF6 (reaction)
  • Reactome Reaction: FGFR3 → FRS2 (reaction)
  • Reactome Reaction: FGF7 → FGF7 (reaction)
  • Reactome Reaction: FGF3 → FGF22 (reaction)
  • Reactome Reaction: FGF4 → FGF9 (reaction)
  • Reactome Reaction: FGF17 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF6 → FGF23 (reaction)
  • Reactome Reaction: FGFR3 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF4 → FGFR1 (reaction)
  • Reactome Reaction: FGF4 → FRS2 (reaction)
  • Reactome Reaction: FGF6 → FRS2 (reaction)
  • Reactome Reaction: FGFR2 → KRAS (reaction)
  • Reactome Reaction: FGF2 → FGF16 (reaction)
  • Reactome Reaction: FGF22 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF3 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF23 (reaction)
  • Reactome Reaction: PIK3CA → PIK3R1 (reaction)
  • Reactome Reaction: FGF2 → GRB2 (reaction)
  • Reactome Reaction: FGF3 → FGF3 (reaction)
  • Reactome Reaction: FGF7 → FGF20 (reaction)
  • Reactome Reaction: FGF8 → FGF9 (reaction)
  • Reactome Reaction: FGF7 → FRS2 (reaction)
  • Reactome Reaction: FGFR1 → KRAS (reaction)
  • Reactome Reaction: FGFR2 → GRB2 (indirect_complex)
  • Reactome Reaction: PIK3CA → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF22 → FGFR3 (reaction)
  • Reactome Reaction: PIK3CA → FGFR2 (reaction)
  • Reactome Reaction: FGF10 → GRB2 (reaction)
  • Reactome Reaction: FGF9 → HRAS (reaction)
  • Reactome Reaction: FGF6 → GRB2 (reaction)
  • Reactome Reaction: FGFR4 → KRAS (reaction)
  • Reactome Reaction: FGF17 → FGFR4 (reaction)
  • Reactome Reaction: FGFR2 → FGFR3 (reaction)
  • Reactome Reaction: FGF6 → FGF6 (reaction)
  • Reactome Reaction: FGF18 → FRS2 (reaction)
  • Reactome Reaction: FGF9 → PIK3CA (reaction)
  • Reactome Reaction: FGFR3 → PIK3CA (reaction)
  • Reactome Reaction: FGF5 → FGF23 (reaction)
  • Reactome Reaction: HRAS → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → PIK3CA (reaction)
  • Reactome Reaction: FGF2 → FGF7 (reaction)
  • Reactome Reaction: FGF9 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGFR1 → FRS2 (reaction)
  • Reactome Reaction: FGFR2 → FGFR2 (reaction)
  • Reactome Reaction: FGF8 → FGF10 (reaction)
  • Reactome Reaction: FGF22 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF22 (reaction)
  • Reactome Reaction: FGFR1 → FGFR2 (reaction)
  • Reactome Reaction: FGF18 → FGF20 (reaction)
  • Reactome Reaction: FGF7 → FGFR2 (reaction)
  • Reactome Reaction: FGF1 → GRB2 (reaction)
  • Reactome Reaction: FGF8 → FGFR1 (reaction)
  • Reactome Reaction: FGF20 → GRB2 (reaction)
  • Reactome Reaction: KRAS → SOS1 (reaction)
  • Reactome Reaction: FGF18 → FGFR3 (reaction)
  • Reactome Reaction: FGF7 → PIK3CA (reaction)
  • Reactome Reaction: FGFR3 → FGFR2 (reaction)
  • Reactome Reaction: FGF18 → FGFR1 (reaction)
  • Reactome Reaction: FGF4 → FGFR4 (reaction)
  • Reactome Reaction: FGFR2 → FGFR1 (reaction)
  • Reactome Reaction: FGF17 → KRAS (reaction)
  • Reactome Reaction: SOS1 → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF5 (reaction)
  • Reactome Reaction: PIK3CA → FGFR1 (reaction)
  • Reactome Reaction: FGFR1 → GRB2 (reaction)
  • Reactome Reaction: FGF2 → FGFR3 (reaction)
  • Reactome Reaction: SOS1 → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF23 → PIK3CA (reaction)
  • Reactome Reaction: FGFR1 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → SOS1 (reaction)
  • Reactome Reaction: FGF10 → FGF22 (reaction)
  • Reactome Reaction: FGF2 → FGF10 (reaction)
  • Reactome Reaction: FGF2 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF22 → SOS1 (reaction)
  • Reactome Reaction: FGF10 → FGF20 (reaction)
  • Reactome Reaction: FGF6 → FGFR1 (reaction)
  • Reactome Reaction: FRS2 → FGFR2 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3CA (reaction)
  • Reactome Reaction: FGF8 → FGF16 (reaction)
  • Reactome Reaction: PIK3CA → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF3 → FGF23 (reaction)
  • Reactome Reaction: FGF2 → FGF20 (reaction)
  • Reactome Reaction: SOS1 → FGFR2 (reaction)
  • Reactome Reaction: FGF1 → FGF10 (reaction)
  • Reactome Reaction: PIK3CA → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF9 (reaction)
  • Reactome Reaction: FGF18 → FGF18 (reaction)
  • Reactome Reaction: HRAS → FRS2 (reaction)
  • Reactome Reaction: FGFR1 → PIK3CA (reaction)
  • Reactome Reaction: FGF3 → FGF5 (reaction)
  • Reactome Reaction: KRAS → FGFR1 (reaction)
  • Reactome Reaction: FGF17 → FRS2 (indirect_complex)
  • Reactome Reaction: FGFR3 → HRAS (reaction)
  • Reactome Reaction: FGFR2 → GRB2 (reaction)
  • Reactome Reaction: FGFR3 → FGFR3 (reaction)
  • Reactome Reaction: FGFR2 → FGFR4 (reaction)
  • Reactome Reaction: FGF3 → FGF18 (reaction)
  • Reactome Reaction: FGF20 → FGF22 (reaction)
  • Reactome Reaction: FGF4 → FGF20 (reaction)
  • Reactome Reaction: FGF1 → FGFR4 (reaction)
  • Reactome Reaction: FGF6 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF18 → GRB2 (reaction)
  • Reactome Reaction: PIK3CA → GAB1 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF3 (reaction)
  • Reactome Reaction: FGF6 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → FGF6 (reaction)
  • Reactome Reaction: FGF1 → FGF20 (reaction)
  • Reactome Reaction: FGFR3 → NRAS (reaction)
  • Reactome Reaction: FGF10 → FGFR2 (reaction)
  • Reactome Reaction: FGF7 → SOS1 (reaction)
  • Reactome Reaction: FGF18 → SOS1 (reaction)
  • Reactome Reaction: FGF6 → FGF16 (reaction)
  • Reactome Reaction: FGF9 → FGF9 (reaction)
  • Reactome Reaction: FGF10 → FGFR1 (reaction)
  • Reactome Reaction: FGF1 → FGF22 (reaction)
  • Reactome Reaction: SOS1 → FRS2 (reaction)
  • Reactome Reaction: FGF7 → HRAS (reaction)
  • Reactome Reaction: FGF3 → FGF4 (reaction)
  • Reactome Reaction: FGF16 → FGF23 (reaction)
  • Reactome Reaction: FGF18 → PIK3CA (reaction)
  • Reactome Reaction: PIK3CA → GAB1 (reaction)
  • Reactome Reaction: FGFR4 → SOS1 (reaction)
  • Reactome Reaction: FGF5 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGFR2 → NRAS (reaction)
  • Reactome Reaction: FGF22 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF3 → FRS2 (reaction)
  • Reactome Reaction: GRB2 → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF6 → FGF17 (reaction)
  • Reactome Reaction: GRB2 → NRAS (reaction)
  • Reactome Reaction: FGF7 → KRAS (reaction)
  • Reactome Reaction: FGF10 → HRAS (reaction)
  • Reactome Reaction: FGF8 → PIK3CA (reaction)
  • Reactome Reaction: FGF18 → FGF22 (reaction)
  • Reactome Reaction: FGF17 → FGFR3 (reaction)
  • Reactome Reaction: FGF20 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF20 → PIK3CA (reaction)
  • Reactome Reaction: FGF10 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF3 → PIK3CA (reaction)
  • Reactome Reaction: FGF4 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF3 → KRAS (reaction)
  • Reactome Reaction: FGF17 → PIK3CA (reaction)
  • Reactome Reaction: GRB2 → FGFR2 (reaction)
  • Reactome Reaction: SOS1 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF4 → FGF22 (reaction)
  • Reactome Reaction: HRAS → SOS1 (reaction)
  • Reactome Reaction: FGFR1 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF16 → GRB2 (reaction)
  • Reactome Reaction: FGF7 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGFR1 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF16 (reaction)
  • Reactome Reaction: GRB2 → FGFR3 (reaction)
  • Reactome Reaction: FGF18 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF23 → FRS2 (reaction)
  • Reactome Reaction: FGF22 → PIK3CA (reaction)
  • Reactome Reaction: FGF22 → FGF23 (reaction)
  • Reactome Reaction: FGF22 → FGFR4 (reaction)
  • Reactome Reaction: FGF8 → FGF22 (reaction)
  • Reactome Reaction: SOS1 → FGFR3 (reaction)
  • Reactome Reaction: FGF16 → FGF18 (reaction)
  • Reactome Reaction: FGF10 → FGF18 (reaction)
  • Reactome Reaction: KRAS → FRS2 (reaction)
  • Reactome Reaction: FGF7 → FGF10 (reaction)
  • Reactome Reaction: FGF8 → FGF18 (reaction)
  • Reactome Reaction: FGF7 → FGF16 (reaction)
  • Reactome Reaction: FGF1 → FGF17 (reaction)
  • Reactome Reaction: FGF7 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → FGFR2 (reaction)
  • Reactome Reaction: FGF18 → FGFR4 (reaction)
  • Reactome Reaction: NRAS → SOS1 (reaction)
  • Reactome Reaction: FGF23 → GRB2 (indirect_complex)
  • Reactome Reaction: SOS1 → FGFR1 (reaction)
  • Reactome Reaction: FGFR4 → GRB2 (reaction)
  • Reactome Reaction: FGF3 → FGF20 (reaction)
  • Reactome Reaction: FGF23 → SOS1 (reaction)
  • Reactome Reaction: FGF16 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGFR4 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF8 → FGF23 (reaction)
  • Reactome Reaction: FGF9 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF3 (reaction)
  • Reactome Reaction: FGFR4 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF9 → FGFR2 (reaction)
  • Reactome Reaction: FGF16 → KRAS (reaction)
  • Reactome Reaction: HRAS → FGFR1 (reaction)
  • Reactome Reaction: FGF20 → SOS1 (reaction)
  • Reactome Reaction: FGF23 → FGFR1 (reaction)
  • Reactome Reaction: FGF8 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF5 → FGF18 (reaction)
  • Reactome Reaction: FGF5 → FGF7 (reaction)
  • Reactome Reaction: FGF22 → FGF22 (reaction)
  • Reactome Reaction: FGFR1 → FGFR1 (reaction)
  • Reactome Reaction: FGF3 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF23 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF8 → FGFR4 (reaction)
  • Reactome Reaction: FGF7 → FGFR1 (reaction)
  • Reactome Reaction: FGF2 → FGF18 (reaction)
  • Reactome Reaction: FGF6 → FGFR3 (reaction)
  • Reactome Reaction: FGF9 → FGF23 (reaction)
  • Reactome Reaction: FGF1 → FGFR3 (reaction)
  • Reactome Reaction: FGF16 → FRS2 (reaction)
  • Reactome Reaction: FGF8 → FGFR3 (reaction)
  • Reactome Reaction: FGF5 → SOS1 (reaction)
  • Reactome Reaction: FGF1 → FGF8 (reaction)
  • Reactome Reaction: FGFR2 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF5 → FGF17 (reaction)
  • Reactome Reaction: FGF20 → FRS2 (reaction)
  • Reactome Reaction: FGF9 → FGF20 (reaction)
  • Reactome Reaction: FGF17 → FGF20 (reaction)
  • Reactome Reaction: FGF2 → FGF17 (reaction)
  • Reactome Reaction: FGF3 → FGFR4 (reaction)
  • Reactome Reaction: FGF4 → FGF10 (reaction)
  • Reactome Reaction: FGF1 → FGF9 (reaction)
  • Reactome Reaction: FGF2 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF6 → HRAS (reaction)
  • Reactome Reaction: FGF9 → FGF22 (reaction)
  • Reactome Reaction: FGFR4 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF16 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → PIK3CA (reaction)
  • Reactome Reaction: FGFR1 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR4 (reaction)
  • Reactome Reaction: FGF22 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF10 (reaction)
  • Reactome Reaction: FGF10 → PIK3CA (reaction)
  • Reactome Reaction: GRB2 → HRAS (reaction)
  • Reactome Reaction: FGFR3 → FGFR1 (reaction)
  • Reactome Reaction: FGF8 → SOS1 (reaction)
  • Reactome Reaction: FGF23 → HRAS (reaction)
  • Reactome Reaction: FGF16 → FGFR1 (reaction)
  • Reactome Reaction: FGF23 → FGFR3 (reaction)
  • Reactome Reaction: FGF22 → NRAS (reaction)
  • Reactome Reaction: FGF7 → FGF17 (reaction)
  • Reactome Reaction: FGF1 → FGF23 (reaction)
  • Reactome Reaction: FGF4 → FGF8 (reaction)
  • Reactome Reaction: FGF1 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → FGFR1 (indirect_complex)
  • Reactome Reaction: SOS1 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF16 → FGFR2 (reaction)
  • Reactome Reaction: FGF6 → FGF20 (reaction)
  • Reactome Reaction: NRAS → FRS2 (reaction)
  • Reactome Reaction: FGF16 → FGFR4 (reaction)
  • Reactome Reaction: FGFR3 → GRB2 (reaction)
  • Reactome Reaction: FGF4 → KRAS (reaction)
  • Reactome Reaction: FGF9 → FGF17 (reaction)
  • Reactome Reaction: FGF4 → FGF5 (reaction)
  • Reactome Reaction: FGF8 → KRAS (reaction)
  • Reactome Reaction: NRAS → FGFR2 (reaction)
  • Reactome Reaction: FRS2 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → FRS2 (reaction)
  • Reactome Reaction: GRB2 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF4 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF7 → FGF9 (reaction)
  • Reactome Reaction: FGF4 → HRAS (reaction)
  • Reactome Reaction: FRS2 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF2 (reaction)
  • Reactome Reaction: FGF10 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF7 → GRB2 (reaction)
  • Reactome Reaction: FGF1 → FRS2 (indirect_complex)
  • Reactome Reaction: PIK3CA → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF20 → KRAS (reaction)
  • Reactome Reaction: FGF3 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF16 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF2 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF1 → NRAS (reaction)
  • Reactome Reaction: FRS2 → FGFR2 (reaction)
  • Reactome Reaction: FGF3 → FGF8 (reaction)
  • Reactome Reaction: FGF10 → FRS2 (reaction)
  • Reactome Reaction: FGF2 → FGF5 (reaction)
  • Reactome Reaction: FGF9 → NRAS (reaction)
  • Reactome Reaction: FGF7 → FGFR4 (reaction)
  • Reactome Reaction: FGF3 → FGF6 (reaction)
  • Reactome Reaction: FGF10 → FGFR4 (reaction)
  • Reactome Reaction: FGF23 → KRAS (reaction)
  • Reactome Reaction: FGF18 → NRAS (reaction)
  • Reactome Reaction: FGF20 → NRAS (reaction)
  • Reactome Reaction: FGF17 → NRAS (reaction)
  • Reactome Reaction: FGF6 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → FGF16 (reaction)
  • Reactome Reaction: FGF9 → SOS1 (reaction)
  • Reactome Reaction: FGF3 → FGFR2 (reaction)
  • Reactome Reaction: FGF2 → FGF4 (reaction)
  • Reactome Reaction: FGF2 → FGFR4 (reaction)
  • Reactome Reaction: FGF20 → FGFR3 (reaction)
  • Reactome Reaction: NRAS → FGFR1 (reaction)
  • Reactome Reaction: FGF22 → FGFR1 (reaction)
  • Reactome Reaction: FGF3 → FGF16 (reaction)
  • Reactome Reaction: FGF6 → FGF7 (reaction)
  • Reactome Reaction: FGFR2 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF7 → FGF8 (reaction)
  • Reactome Reaction: FGFR1 → GRB2 (indirect_complex)
  • Reactome Reaction: FGFR4 → NRAS (reaction)
  • Reactome Reaction: FGF4 → NRAS (reaction)
  • Reactome Reaction: FGF8 → FRS2 (reaction)
  • Reactome Reaction: FGF20 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF16 → NRAS (reaction)
  • Reactome Reaction: FGFR2 → SOS1 (indirect_complex)
  • Reactome Reaction: HRAS → FGFR3 (reaction)
  • Reactome Reaction: FGF22 → GRB2 (reaction)
  • Reactome Reaction: FGF8 → FGF8 (reaction)
  • Reactome Reaction: FGF5 → FGF16 (reaction)
  • Reactome Reaction: FGF6 → FGF18 (reaction)
  • Reactome Reaction: FGF22 → FGFR2 (reaction)
  • Reactome Reaction: PIK3CA → FGFR3 (reaction)
  • Reactome Reaction: GRB2 → FGFR1 (reaction)
  • Reactome Reaction: FGF20 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF10 → KRAS (reaction)
  • Reactome Reaction: FGF9 → FGFR3 (reaction)
  • Reactome Reaction: FGFR3 → SOS1 (reaction)
  • Reactome Reaction: GRB2 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → FGF18 (reaction)
  • Reactome Reaction: FGF1 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF17 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF2 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF6 → SOS1 (reaction)
  • Reactome Reaction: FGF1 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF10 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF6 (reaction)
  • Reactome Reaction: FGF17 → SOS1 (reaction)
  • Reactome Reaction: FGF16 → FGF17 (reaction)
  • Reactome Reaction: FGF2 → HRAS (reaction)
  • Reactome Reaction: FGFR4 → PIK3CA (reaction)
  • Reactome Reaction: FGF20 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF6 → FGF9 (reaction)
  • Reactome Reaction: FGF23 → FGF23 (reaction)
  • Reactome Reaction: FGF5 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF4 (reaction)
  • Reactome Reaction: FGF9 → GRB2 (reaction)
  • Reactome Reaction: PIK3CA → FRS2 (indirect_complex)
  • Reactome Reaction: FGF16 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF6 → PIK3CA (reaction)
  • Reactome Reaction: FGF9 → KRAS (reaction)
  • Reactome Reaction: FGF1 → FGF7 (reaction)
  • Reactome Reaction: FGF3 → SOS1 (reaction)
  • Reactome Reaction: FGF2 → NRAS (reaction)
  • Reactome Reaction: FGF6 → FGFR2 (reaction)
  • Reactome Reaction: FGF20 → HRAS (reaction)
  • Reactome Reaction: FGF8 → FGF17 (reaction)
  • Reactome Reaction: FGF7 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF3 → NRAS (reaction)
  • Reactome Reaction: FGF6 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF18 (reaction)
  • Reactome Reaction: FGF23 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF8 → FGFR2 (reaction)
  • Reactome Reaction: FGFR4 → FRS2 (indirect_complex)
  • Reactome Reaction: NRAS → FGFR3 (reaction)
  • Reactome Reaction: FGF6 → NRAS (reaction)
  • Reactome Reaction: FGF5 → NRAS (reaction)
  • Reactome Reaction: FGF20 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → FGFR3 (reaction)
  • Reactome Reaction: FGF4 → GRB2 (reaction)
  • Reactome Reaction: FGF20 → FGFR4 (reaction)
  • Reactome Reaction: FGF17 → FGF23 (reaction)
  • Reactome Reaction: FGF2 → KRAS (reaction)
  • Reactome Reaction: FGF10 → FGF23 (reaction)
  • Reactome Reaction: FGF5 → FGF20 (reaction)
  • Reactome Reaction: FRS2 → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF3 → FGFR1 (reaction)
  • Reactome Reaction: FGF6 → FGF10 (reaction)
  • Reactome Reaction: FGF4 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → SOS1 (reaction)
  • Reactome Reaction: FGF7 → SOS1 (indirect_complex)
  • Reactome Reaction: FGF18 → HRAS (reaction)
  • Reactome Reaction: PIK3CA → FRS2 (reaction)
  • Reactome Reaction: FGF4 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF9 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR1 (reaction)
  • Reactome Reaction: FGF3 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → FRS2 (reaction)
  • Reactome Reaction: FGF8 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR3 (reaction)
In total, 366 gene pairs are associated to this article in curated databases