Gene interactions and pathways from curated databases and text-mining
Biochem Biophys Res Commun 2013, PMID: 23567973

Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug.

Lee, Yunhee; Lee, Mira; Kim, Semi

Binding of Gas6 to Axl (Gas6/Axl axis) alters cellular functions, including migration, invasion, proliferation, and survival. However, the molecular mechanisms underlying Gas6-mediated cell migration remain poorly understood. In this study, we found that Gas6 induced the activation of JNK and ERK1/2 signaling in cancer cells expressing Axl, resulting in the phosphorylation of activator protein-1 (AP-1) transcription factors c-Jun and ATF-2, and induction of Slug. Depletion of c-Jun or ATF-2 by siRNA attenuated the Gas6-induced expression of Slug. Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6. These results suggest that Gas6 induced cell migration via Slug upregulation in JNK- and ERK1/2-dependent mechanisms. These data provide an important insight into the molecular mechanisms mediating Gas6-induced cell migration.

Diseases/Pathways annotated by Medline MESH: MAP Kinase Signaling System, Neoplasm Invasiveness
Document information provided by NCBI PubMed

Text Mining Data

Slug → Gas6: " Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug "

MAPK → Gas6: " Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug "

ERK1/2 → Gas6: " In this study, we found that Gas6 induced the activation of JNK and ERK1/2 signaling in cancer cells expressing Axl, resulting in the phosphorylation of activator protein-1 (AP-1) transcription factors c-Jun and ATF-2, and induction of Slug "

Slug → Gas6: " Depletion of c-Jun or ATF-2 by siRNA attenuated the Gas6 induced expression of Slug "

Slug → c-Jun: " Depletion of c-Jun or ATF-2 by siRNA attenuated the Gas6 induced expression of Slug "

Slug → ATF-2: " Depletion of c-Jun or ATF-2 by siRNA attenuated the Gas6 induced expression of Slug "

reduction/vimentin → Slug: " Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6 "

reduction/vimentin → E-cadherin: " Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6 "

reduction/vimentin → Gas6: " Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6 "

E-cadherin → Slug: " Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6 "

E-cadherin → Gas6: " Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6 "

Manually curated Databases

No curated data.