Gene interactions and pathways from curated databases and text-mining
Biochem Biophys Res Commun 1986, PMID: 3486658

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages.

Bachwich, P R; Chensue, S W; Larrick, J W; Kunkel, S L

We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages. Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10(-8) M. While indomethacin decreased tumor necrosis factor induced PGE2 production, this cyclooxygenase inhibitor augmented tumor necrosis factor induced interleukin-1 production. Our data suggests that tumor necrosis factor may be an important immunopotentiating agent in addition to its previously described cytolytic and metabolic activities.

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Text Mining Data

interleukin-1 → Tumor necrosis factor: " Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages "

interleukin-1 — tumor necrosis factor: " We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages "

interleukin-1 → Tumor necrosis factor: " Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M "

Manually curated Databases

No curated data.