Gene interactions and pathways from curated databases and text-mining
J Biol Chem 1994, PMID: 8034659

Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1.

Ng, S B; Tan, Y H; Guy, G R

Although tumor necrosis factor (TNF) and interleukin-1 (IL) induce the expression of the IL-8, TNF-stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested. IL-1 induces IL-6 gene expression after 30 min of IL-1 treatment, reaching a maximum level by 7 h, and is sustained for up to 14 h. TNF also induces the IL-6 gene expression at 30 min but the induction was low. A similar differences in the amount of IL-6 secreted was observed in the IL-1/TNF-treated cells. Measurement of IL-6 gene transcription by nuclear run-on transcription assays indicated a 4-fold higher rate of IL-6 gene transcription in IL-1-treated than in TNF-treated cells. The IL-1-induced IL-6 mRNA has a significantly longer half-life (> 6 h) compared to 30 min for TNF-treated cells. These results suggest that the induction of the IL-6 gene expression in primary human fibroblasts by TNF and IL-1 is differentially regulated at the transcriptional as well as at the post-transcriptional level.

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Text Mining Data

interleukin-6 → interleukin-1: " Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1 "

interleukin-6 → tumor necrosis factor: " Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1 "

interleukin-1 ( IL ) → IL-8: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

interleukin-1 ( IL ) → NF-kappa B: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

interleukin-1 ( IL ) → plasminogen: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

tumor necrosis factor (TNF) → IL-8: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

tumor necrosis factor (TNF) → NF-kappa B: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

tumor necrosis factor (TNF) → plasminogen: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

NF-kappa B → plasminogen: " Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested "

IL-1 → IL-6: " IL-1 induces IL-6 gene expression after 30 min of IL-1 treatment, reaching a maximum level by 7 h, and is sustained for up to 14 h. TNF also induces the IL-6 gene expression at 30 min but the induction was low "

IL-6 → TNF: " These results suggest that the induction of the IL-6 gene expression in primary human fibroblasts by TNF and IL-1 is differentially regulated at the transcriptional as well as at the post-transcriptional level "

IL-6 → IL-1: " These results suggest that the induction of the IL-6 gene expression in primary human fibroblasts by TNF and IL-1 is differentially regulated at the transcriptional as well as at the post-transcriptional level "

Manually curated Databases

No curated data.