Gene interactions and pathways from curated databases and text-mining
Cell 1994, PMID: 8069916

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

Rothe, M; Wong, S C; Henzel, W J; Goeddel, D V

Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor necrosis factor receptor (TNF-R2) that is required for signal transduction. This region was subsequently shown to mediate the interaction of cytoplasmic factors with TNF-R2. Two of these factors were isolated and molecularly cloned using biochemical purification and the yeast two-hybrid system. TNF receptor-associated factor 1 (TRAF1) and TRAF2 are the first two members of a novel protein family containing a novel C-terminal homology region, the TRAF domain. In addition, TRAF2 contains an N-terminal RING finger motif. TRAF1 and TRAF2 can form homo- and heterotypic dimers. Our analysis indicates that TRAF1 and TRAF2 are associated with the cytoplasmic domain of TNF-R2 in a heterodimeric complex in which TRAF2 contacts the receptor directly. TRAF1 interacts with TNF-R2 indirectly through heterodimer formation with TRAF2.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: TRAF2 — TNFRSF1B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRAF2 — TNFRSF1B (direct interaction, two hybrid)
  • IRef Biogrid Interaction: TRAF1 — TRAF1 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: TRAF1 — TRAF2 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: TRAF2 — TRAF2 (direct interaction, two hybrid)
  • IRef Biogrid Interaction: TRAF1 — TNFRSF1B (direct interaction, two hybrid)
  • IRef Hprd Interaction: TRAF1 — TRAF2 (in vitro)
  • IRef Hprd Interaction: TRAF1 — TRAF2 (in vivo)
  • IRef Hprd Interaction: TRAF1 — TRAF2 (two hybrid)
  • IRef Hprd Interaction: TRAF1 — TRAF2 (in vivo)
  • IRef Hprd Interaction: TRAF1 — TRAF2 (two hybrid)
  • IRef Hprd Interaction: TRAF2 — TRAF2 (in vivo)
  • IRef Hprd Interaction: TRAF2 — TRAF2 (in vitro)
  • IRef Hprd Interaction: TRAF2 — TRAF2 (two hybrid)
  • IRef Intact Interaction: TRAF2 — TNFRSF1B (physical association, two hybrid)
  • IRef Intact Interaction: TRAF1 — TRAF1 (physical association, two hybrid)
  • IRef Intact Interaction: TRAF1 — TRAF2 (physical association, two hybrid)
  • IRef Intact Interaction: TRAF2 — TRAF2 (physical association, two hybrid)
  • IRef Intact Interaction: TRAF1 — TNFRSF1B (physical association, two hybrid)
  • IRef Ophid Interaction: TRAF2 — TNFRSF1B (aggregation, confirmational text mining)
  • IRef Ophid Interaction: TRAF1 — TRAF2 (aggregation, confirmational text mining)
  • IRef Ophid Interaction: TRAF1 — TNFRSF1B (aggregation, confirmational text mining)
  • NCI Pathway Database TNF receptor signaling pathway : TNF-alpha/TNFR2 (cleaved) complex (TNFRSF1B-TNF) → TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database TNF receptor signaling pathway : TNF-alpha/TNFR2 (cleaved) complex (TNFRSF1B-TNF) → TRAF1/TRAF2 complex (TRAF1-TRAF2) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database TNF receptor signaling pathway : TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF) → TRAF1/TRAF2 complex (TRAF1-TRAF2) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction
In total, 10 gene pairs are associated to this article in curated databases