Neurosurgery 1995,
PMID: 8559306
Yin, D; Kondo, S; Barnett, G H; Morimura, T; Takeuchi, J
In this study, we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the viability of rat glioma (C6) cells and induced apoptosis but did not affect the viability of rat newborn brain, mainly astroglial cells. The antitumor activity of TNF-alpha against C6 cells was partially inhibited by actinomycin D and cycloheximide, suggesting that it is possibly dependent upon new ribonucleic acid and protein synthesis. The results of immunoblotting assay demonstrated that TNF-alpha decreased the expression of mutant p53 protein but induced the expression of wild-type p53 in C6 cells during apoptosis. We suggest that TNF-alpha may activate the function of wild-type p53 protein by the suppression of mutant p53, at least indirectly, and induce p53-dependent apoptosis in glioma cells.
Diseases/Pathways annotated by Medline MESH: Brain Neoplasms, Glioma
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Text Mining Data
p53 → TNF-alpha: "
The results of immunoblotting assay demonstrated that
TNF-alpha decreased the expression of mutant p53 protein but
induced the expression of wild-type
p53 in C6 cells during apoptosis
"
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No curated data.