Gene interactions and pathways from curated databases and text-mining
Eur J Biochem 1996, PMID: 9022680

Interleukin-1 beta induces nuclear factor kappa B in epithelial cells independently of the production of reactive oxygen intermediates.

Bonizzi, G; Dejardin, E; Piret, B; Piette, J; Merville, M P; Bours, V

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) in various cell types. Several studies have indicated that NF-kappa B activation depends strictly on the production of reactive oxygen intermediates. In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines (OVCAR-3, SKOV-3, MCF7 A/Z). In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105. We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2. Our study demonstrated that several signaling pathways lead to the activation of NF-kappa B, following IL-1 beta treatment in different cell types.

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Text Mining Data

NF-kappa B → IL-1 beta: " In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines ( OVCAR-3, SKOV-3, MCF7 A/Z ) "

IL-1 → NF-kappa B: " In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105 "

IL-1 beta → NF-kappa B: " In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105 "

I kappa B-alpha → IL-1: " In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha , while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105 "

I kappa B-alpha → IL-1 beta: " In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha , while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105 "

I kappa B-alpha → NF-kappa B: " In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha , while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105 "

NF-kappa B → IL-1 beta: " We showed that IL-1 beta mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2 "

Manually curated Databases

No curated data.