J Biol Chem 1998,
PMID: 9468499
Bae, Y S; Cantley, L G; Chen, C S; Kim, S R; Kwon, K S; Rhee, S G
Signal transduction across cell membranes often involves the activation of both phosphatidylinositol (PI)-specific phospholipase C (PLC) and phosphoinositide 3-kinase (PI 3-kinase). Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a substrate for both enzymes, is converted to phosphatidylinositol 3,4, 5-trisphosphate (PI(3,4,5)P3) by the action of PI 3-kinase. Here, we show that PI(3,4,5)P3 activates purified PLC-gamma isozymes by interacting with their Src homology 2 domains. Furthermore, the expression of an activated catalytic subunit of PI 3-kinase in COS-7 cells resulted in an increase in inositol phosphate formation, whereas platelet-derived growth factor-induced PLC activation in NIH 3T3 cells was markedly inhibited by the specific PI 3-kinase inhibitor LY294002. These results suggest that receptors coupled to PI 3-kinase may activate PLC-gamma isozymes indirectly, in the absence of PLC-gamma tyrosine phosphorylation, through the generation of PI(3,4,5)P3.
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Text Mining Data
PLC → PI 3-kinase: "
Furthermore, the expression of an activated catalytic subunit of PI 3-kinase in COS-7 cells resulted in an increase in inositol phosphate formation, whereas platelet derived growth factor induced
PLC activation in NIH 3T3 cells was markedly
inhibited by the specific
PI 3-kinase inhibitor LY294002
"
Manually curated Databases
-
Reactome Reaction:
CD79B
→
NCK1
(indirect_complex)
-
Reactome Reaction:
SYK
→
SHC1
(indirect_complex)
-
Reactome Reaction:
IGHM
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
IGKV4-1
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
CBLB
(indirect_complex)
-
Reactome Reaction:
CD79B
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
SH3KBP1
(indirect_complex)
-
Reactome Reaction:
PIK3CD
→
PIK3AP1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGHM
(indirect_complex)
-
Reactome Reaction:
IGKV4-1
→
VAV1
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
BLNK
(indirect_complex)
-
Reactome Reaction:
IGKV1-5
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
IGHM
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGKV1-5
(indirect_complex)
-
Reactome Reaction:
PIK3CD
→
VAV1
(indirect_complex)
-
Reactome Reaction:
PIK3R1
→
VAV1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
BLNK
(indirect_complex)
-
Reactome Reaction:
SOS1
→
VAV1
(indirect_complex)
-
Reactome Reaction:
VAV1
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
SYK
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
SHC1
(direct_complex)
-
Reactome Reaction:
GRB2
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
SYK
→
NCK1
(indirect_complex)
-
Reactome Reaction:
BTK
→
SYK
(indirect_complex)
-
Reactome Reaction:
CD79A
→
SHC1
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
NCK1
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
PIK3R1
→
PIK3AP1
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
VAV1
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGKV4-1
(indirect_complex)
-
Reactome Reaction:
IGKV4-1
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
CD79A
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
SHC1
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
IGHD
→
VAV1
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
SHC1
(indirect_complex)
-
Reactome Reaction:
SYK
→
VAV1
(indirect_complex)
-
Reactome Reaction:
SHC1
→
BLNK
(indirect_complex)
-
Reactome Reaction:
CD79B
→
VAV1
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
IGKC
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
SHC1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGKC
(indirect_complex)
-
Reactome Reaction:
BTK
→
NCK1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
VAV1
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
VAV1
(indirect_complex)
-
Reactome Reaction:
SHC1
→
CBLB
(indirect_complex)
-
Reactome Reaction:
VAV1
→
BLNK
(indirect_complex)
-
Reactome Reaction:
GRB2
→
VAV1
(indirect_complex)
-
Reactome Reaction:
CBL
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
BTK
→
SHC1
(indirect_complex)
-
Reactome Reaction:
GRB2
→
PIK3R1
(indirect_complex)
-
Reactome Reaction:
GRB2
→
SHC1
(indirect_complex)
-
Reactome Reaction:
IGKC
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
SOS1
(indirect_complex)
-
Reactome Reaction:
SHC1
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
BTK
→
CBL
(indirect_complex)
-
Reactome Reaction:
GRB2
→
NCK1
(indirect_complex)
-
Reactome Reaction:
IGKV4-1
→
NCK1
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
SOS1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
NCK1
→
VAV1
(direct_complex)
-
Reactome Reaction:
PLCG2
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
IGHD
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
BTK
→
CD79B
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
CBLB
(indirect_complex)
-
Reactome Reaction:
BTK
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
BTK
→
BLNK
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
VAV1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
SOS1
(indirect_complex)
-
Reactome Reaction:
IGKV1-5
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
IGHM
→
VAV1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
IGHM
→
NCK1
(indirect_complex)
-
Reactome Reaction:
CD79A
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
GRB2
→
PIK3CD
(indirect_complex)
-
Reactome Reaction:
IGHD
→
NCK1
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
BLNK
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
BTK
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
CBLB
(indirect_complex)
-
Reactome Reaction:
NCK1
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
BTK
→
CD79A
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
IGHD
→
SHC1
(indirect_complex)
-
Reactome Reaction:
IGKC
→
SHC1
(indirect_complex)
-
Reactome Reaction:
SOS1
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
VAV1
→
CBLB
(indirect_complex)
-
Reactome Reaction:
CD19
→
PIK3R1
(indirect_complex)
-
Reactome Reaction:
CD19
→
PIK3CD
(indirect_complex)
-
Reactome Reaction:
GRB2
→
VAV1
(direct_complex)
-
Reactome Reaction:
PLCG2
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
IGHD
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
CBLB
(indirect_complex)
-
Reactome Reaction:
IGKC
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
IGKV1-5
→
NCK1
(indirect_complex)
-
Reactome Reaction:
IGKV4-1
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
CD19
→
GRB2
(direct_complex)
-
Reactome Reaction:
CBL
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
SYK
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
CD79A
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
CD79A
→
VAV1
(indirect_complex)
-
Reactome Reaction:
NCK1
→
SH3KBP1
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
SH3KBP1
(indirect_complex)
-
Reactome Reaction:
SHC1
→
IGLC7
(indirect_complex)
-
Reactome Reaction:
SYK
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
BTK
→
VAV1
(indirect_complex)
-
Reactome Reaction:
SOS1
→
SHC1
(indirect_complex)
-
Reactome Reaction:
IGKV1-5
→
VAV1
(indirect_complex)
-
Reactome Reaction:
BTK
→
CBLB
(indirect_complex)
-
Reactome Reaction:
BTK
→
GRB2
(indirect_complex)
-
Reactome Reaction:
SHC1
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
CBL
→
VAV1
(indirect_complex)
-
Reactome Reaction:
IGHD
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
NCK1
→
BLNK
(indirect_complex)
-
Reactome Reaction:
VAV1
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
CBL
→
NCK1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
VAV1
→
SHC1
(direct_complex)
-
Reactome Reaction:
IGHM
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
CBL
→
SHC1
(indirect_complex)
-
Reactome Reaction:
SH3KBP1
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
IGKC
→
VAV1
(indirect_complex)
-
Reactome Reaction:
CD79A
→
NCK1
(indirect_complex)
-
Reactome Reaction:
VAV1
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
NCK1
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
PLCG2
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
NCK1
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
BTK
→
SH3KBP1
(indirect_complex)
-
Reactome Reaction:
SHC1
→
IGLC1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGLC6
(indirect_complex)
-
Reactome Reaction:
IGKC
→
NCK1
(indirect_complex)
-
Reactome Reaction:
CD79B
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
VAV1
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
IGKV1-5
→
SHC1
(indirect_complex)
-
Reactome Reaction:
BTK
→
SOS1
(indirect_complex)
-
Reactome Reaction:
CBL
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
CD19
→
VAV1
(direct_complex)
-
Reactome Reaction:
NCK1
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
IGLC3
(indirect_complex)
-
Reactome Reaction:
DAPP1
→
IGLC2
(indirect_complex)
-
Reactome Reaction:
BTK
→
DAPP1
(indirect_complex)
-
Reactome Reaction:
CD79B
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
PLCG1
→
SHC1
(indirect_complex)
-
Reactome Reaction:
IGHM
→
SHC1
(indirect_complex)
-
Reactome Reaction:
VAV1
→
SH3KBP1
(indirect_complex)
-
Reactome Reaction:
IGKV4-1
→
SHC1
(indirect_complex)
-
Reactome Reaction:
BTK
→
IGHD
(indirect_complex)
-
Reactome Reaction:
CD79B
→
SHC1
(indirect_complex)
-
Reactome Reaction:
GRB2
→
PLCG1
(indirect_complex)
-
Reactome Reaction:
IGKV1-5
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
GRB2
→
PLCG2
(indirect_complex)
-
Reactome Reaction:
SH3KBP1
→
SHC1
(indirect_complex)
In total, 163 gene pairs are associated to this article in curated databases