Gene interactions and pathways from curated databases and text-mining
J Biol Chem 1998, PMID: 9468499

Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate.

Bae, Y S; Cantley, L G; Chen, C S; Kim, S R; Kwon, K S; Rhee, S G

Signal transduction across cell membranes often involves the activation of both phosphatidylinositol (PI)-specific phospholipase C (PLC) and phosphoinositide 3-kinase (PI 3-kinase). Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a substrate for both enzymes, is converted to phosphatidylinositol 3,4, 5-trisphosphate (PI(3,4,5)P3) by the action of PI 3-kinase. Here, we show that PI(3,4,5)P3 activates purified PLC-gamma isozymes by interacting with their Src homology 2 domains. Furthermore, the expression of an activated catalytic subunit of PI 3-kinase in COS-7 cells resulted in an increase in inositol phosphate formation, whereas platelet-derived growth factor-induced PLC activation in NIH 3T3 cells was markedly inhibited by the specific PI 3-kinase inhibitor LY294002. These results suggest that receptors coupled to PI 3-kinase may activate PLC-gamma isozymes indirectly, in the absence of PLC-gamma tyrosine phosphorylation, through the generation of PI(3,4,5)P3.

Document information provided by NCBI PubMed

Text Mining Data

PLC → PI 3-kinase: " Furthermore, the expression of an activated catalytic subunit of PI 3-kinase in COS-7 cells resulted in an increase in inositol phosphate formation, whereas platelet derived growth factor induced PLC activation in NIH 3T3 cells was markedly inhibited by the specific PI 3-kinase inhibitor LY294002 "

Manually curated Databases

  • Reactome Reaction: CD79B → NCK1 (indirect_complex)
  • Reactome Reaction: SYK → SHC1 (indirect_complex)
  • Reactome Reaction: IGHM → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → CBLB (indirect_complex)
  • Reactome Reaction: CD79B → DAPP1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: PIK3CD → PIK3AP1 (indirect_complex)
  • Reactome Reaction: BTK → IGHM (indirect_complex)
  • Reactome Reaction: IGKV4-1 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG1 → BLNK (indirect_complex)
  • Reactome Reaction: IGKV1-5 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGHM → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → IGKV1-5 (indirect_complex)
  • Reactome Reaction: PIK3CD → VAV1 (indirect_complex)
  • Reactome Reaction: PIK3R1 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → BLNK (indirect_complex)
  • Reactome Reaction: SOS1 → VAV1 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC3 (indirect_complex)
  • Reactome Reaction: SYK → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → SHC1 (direct_complex)
  • Reactome Reaction: GRB2 → DAPP1 (indirect_complex)
  • Reactome Reaction: SYK → NCK1 (indirect_complex)
  • Reactome Reaction: BTK → SYK (indirect_complex)
  • Reactome Reaction: CD79A → SHC1 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC6 (indirect_complex)
  • Reactome Reaction: NCK1 → PLCG2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → PIK3AP1 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC6 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → IGKV4-1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → PLCG2 (indirect_complex)
  • Reactome Reaction: CD79A → PLCG2 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC3 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGHD → VAV1 (indirect_complex)
  • Reactome Reaction: DAPP1 → SHC1 (indirect_complex)
  • Reactome Reaction: SYK → VAV1 (indirect_complex)
  • Reactome Reaction: SHC1 → BLNK (indirect_complex)
  • Reactome Reaction: CD79B → VAV1 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC3 (indirect_complex)
  • Reactome Reaction: BTK → IGLC1 (indirect_complex)
  • Reactome Reaction: IGKC → PLCG1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → IGKC (indirect_complex)
  • Reactome Reaction: BTK → NCK1 (indirect_complex)
  • Reactome Reaction: NCK1 → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC7 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC6 (indirect_complex)
  • Reactome Reaction: PLCG1 → VAV1 (indirect_complex)
  • Reactome Reaction: SHC1 → CBLB (indirect_complex)
  • Reactome Reaction: VAV1 → BLNK (indirect_complex)
  • Reactome Reaction: GRB2 → VAV1 (indirect_complex)
  • Reactome Reaction: CBL → PLCG2 (indirect_complex)
  • Reactome Reaction: PLCG1 → DAPP1 (indirect_complex)
  • Reactome Reaction: BTK → SHC1 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3R1 (indirect_complex)
  • Reactome Reaction: GRB2 → SHC1 (indirect_complex)
  • Reactome Reaction: IGKC → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → SOS1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → CBL (indirect_complex)
  • Reactome Reaction: GRB2 → NCK1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → NCK1 (indirect_complex)
  • Reactome Reaction: PLCG1 → SOS1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC2 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC2 (indirect_complex)
  • Reactome Reaction: NCK1 → VAV1 (direct_complex)
  • Reactome Reaction: PLCG2 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGHD → DAPP1 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → CD79B (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC1 (indirect_complex)
  • Reactome Reaction: PLCG1 → CBLB (indirect_complex)
  • Reactome Reaction: BTK → PLCG1 (indirect_complex)
  • Reactome Reaction: BTK → BLNK (indirect_complex)
  • Reactome Reaction: PLCG2 → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → SOS1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → PLCG1 (indirect_complex)
  • Reactome Reaction: IGHM → VAV1 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC6 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC7 (indirect_complex)
  • Reactome Reaction: IGHM → NCK1 (indirect_complex)
  • Reactome Reaction: CD79A → DAPP1 (indirect_complex)
  • Reactome Reaction: GRB2 → PIK3CD (indirect_complex)
  • Reactome Reaction: IGHD → NCK1 (indirect_complex)
  • Reactome Reaction: DAPP1 → BLNK (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC7 (indirect_complex)
  • Reactome Reaction: BTK → PLCG2 (indirect_complex)
  • Reactome Reaction: DAPP1 → CBLB (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → CD79A (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC2 (indirect_complex)
  • Reactome Reaction: IGHD → SHC1 (indirect_complex)
  • Reactome Reaction: IGKC → SHC1 (indirect_complex)
  • Reactome Reaction: SOS1 → DAPP1 (indirect_complex)
  • Reactome Reaction: VAV1 → CBLB (indirect_complex)
  • Reactome Reaction: CD19 → PIK3R1 (indirect_complex)
  • Reactome Reaction: CD19 → PIK3CD (indirect_complex)
  • Reactome Reaction: GRB2 → VAV1 (direct_complex)
  • Reactome Reaction: PLCG2 → IGLC7 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC1 (indirect_complex)
  • Reactome Reaction: IGHD → PLCG1 (indirect_complex)
  • Reactome Reaction: PLCG2 → CBLB (indirect_complex)
  • Reactome Reaction: IGKC → PLCG2 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → NCK1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → PLCG1 (indirect_complex)
  • Reactome Reaction: CD19 → GRB2 (direct_complex)
  • Reactome Reaction: CBL → DAPP1 (indirect_complex)
  • Reactome Reaction: SYK → PLCG1 (indirect_complex)
  • Reactome Reaction: CD79A → PLCG1 (indirect_complex)
  • Reactome Reaction: CD79A → VAV1 (indirect_complex)
  • Reactome Reaction: NCK1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: PLCG1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC7 (indirect_complex)
  • Reactome Reaction: SYK → PLCG2 (indirect_complex)
  • Reactome Reaction: BTK → VAV1 (indirect_complex)
  • Reactome Reaction: SOS1 → SHC1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → VAV1 (indirect_complex)
  • Reactome Reaction: BTK → CBLB (indirect_complex)
  • Reactome Reaction: BTK → GRB2 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC6 (indirect_complex)
  • Reactome Reaction: CBL → VAV1 (indirect_complex)
  • Reactome Reaction: IGHD → PLCG2 (indirect_complex)
  • Reactome Reaction: NCK1 → BLNK (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC1 (indirect_complex)
  • Reactome Reaction: CBL → NCK1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC3 (indirect_complex)
  • Reactome Reaction: VAV1 → SHC1 (direct_complex)
  • Reactome Reaction: IGHM → PLCG2 (indirect_complex)
  • Reactome Reaction: CBL → SHC1 (indirect_complex)
  • Reactome Reaction: SH3KBP1 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGKC → VAV1 (indirect_complex)
  • Reactome Reaction: CD79A → NCK1 (indirect_complex)
  • Reactome Reaction: VAV1 → IGLC2 (indirect_complex)
  • Reactome Reaction: NCK1 → DAPP1 (indirect_complex)
  • Reactome Reaction: PLCG2 → IGLC3 (indirect_complex)
  • Reactome Reaction: NCK1 → IGLC6 (indirect_complex)
  • Reactome Reaction: BTK → SH3KBP1 (indirect_complex)
  • Reactome Reaction: SHC1 → IGLC1 (indirect_complex)
  • Reactome Reaction: BTK → IGLC6 (indirect_complex)
  • Reactome Reaction: IGKC → NCK1 (indirect_complex)
  • Reactome Reaction: CD79B → PLCG1 (indirect_complex)
  • Reactome Reaction: VAV1 → DAPP1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → SOS1 (indirect_complex)
  • Reactome Reaction: CBL → PLCG1 (indirect_complex)
  • Reactome Reaction: CD19 → VAV1 (direct_complex)
  • Reactome Reaction: NCK1 → IGLC3 (indirect_complex)
  • Reactome Reaction: PLCG1 → IGLC3 (indirect_complex)
  • Reactome Reaction: DAPP1 → IGLC2 (indirect_complex)
  • Reactome Reaction: BTK → DAPP1 (indirect_complex)
  • Reactome Reaction: CD79B → PLCG2 (indirect_complex)
  • Reactome Reaction: PLCG1 → SHC1 (indirect_complex)
  • Reactome Reaction: IGHM → SHC1 (indirect_complex)
  • Reactome Reaction: VAV1 → SH3KBP1 (indirect_complex)
  • Reactome Reaction: IGKV4-1 → SHC1 (indirect_complex)
  • Reactome Reaction: BTK → IGHD (indirect_complex)
  • Reactome Reaction: CD79B → SHC1 (indirect_complex)
  • Reactome Reaction: GRB2 → PLCG1 (indirect_complex)
  • Reactome Reaction: IGKV1-5 → PLCG2 (indirect_complex)
  • Reactome Reaction: GRB2 → PLCG2 (indirect_complex)
  • Reactome Reaction: SH3KBP1 → SHC1 (indirect_complex)
In total, 163 gene pairs are associated to this article in curated databases