Gene interactions and pathways from curated databases and text-mining
Nature 1998, PMID: 9510247

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.

Chen, L; Glover, J N; Hogan, P G; Rao, A; Harrison, S C

The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the bending of Fos and DNA. The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Bind Interaction: JUN — NFATC2
  • IRef Bind Interaction: JUN — NFATC2
  • IRef Bind Interaction: JUN — NFATC2
  • IRef Bind Interaction: JUN — JUN
  • IRef Bind_translation Interaction: JUN — NFATC2 (x-ray crystallography)
  • IRef Bind_translation Interaction: JUN — JUN (x-ray crystallography)
  • MIPS CORUM NFAT-JUN-FOS DNA-protein complex: NFAT-JUN-FOS DNA-protein complex complex (FOS-JUN-NFATC2)
  • IRef Hprd Interaction: Complex of FOS-JUN-NFATC2-JUN-FOS-NFATC2-NFATC2-FOS-JUN (in vivo)
  • NCI Pathway Database AP-1 transcription factor network: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database AP-1 transcription factor network: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS complex (FOS-JUN) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database AP-1 transcription factor network: JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN/FOS complex (FOS-JUN) (modification, collaborate)
    Evidence: physical interaction
In total, 15 gene pairs are associated to this article in curated databases