Nature 1998,
PMID: 9510247
Chen, L; Glover, J N; Hogan, P G; Rao, A; Harrison, S C
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the bending of Fos and DNA. The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs.
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Text Mining Data
Dashed line = No text mining data
Manually curated Databases
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IRef Bind Interaction:
JUN
—
NFATC2
-
IRef Bind Interaction:
JUN
—
NFATC2
-
IRef Bind Interaction:
JUN
—
NFATC2
-
IRef Bind Interaction:
JUN
—
JUN
-
IRef Bind_translation Interaction:
JUN
—
NFATC2
(x-ray crystallography)
-
IRef Bind_translation Interaction:
JUN
—
JUN
(x-ray crystallography)
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MIPS CORUM NFAT-JUN-FOS DNA-protein complex:
NFAT-JUN-FOS DNA-protein complex complex (FOS-JUN-NFATC2)
-
IRef Hprd Interaction:
Complex of FOS-JUN-NFATC2-JUN-FOS-NFATC2-NFATC2-FOS-JUN
(in vivo)
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NCI Pathway Database AP-1 transcription factor network:
NFAT1-c-4-active (NFATC1/NFATC2/NFATC3)
→
JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
NFAT1-c-4-active (NFATC1/NFATC2/NFATC3)
→
JUN/FOS complex (FOS-JUN)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
→
JUN/FOS complex (FOS-JUN)
(modification, collaborate)
Evidence: physical interaction
In total, 15 gene pairs are associated to this article in curated databases