Mol Cell 1998,
PMID: 9660950
Zhong, H; Voll, R E; Ghosh, S
The transcriptional activity of NF-kappa B is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase A (PKA). The transcriptional coactivator CPB/p300 associates with NF-kappa B p65 through two sites, an N-terminal domain that interacts with the C-terminal region of unphosphorylated p65, and a second domain that only interacts with p65 phosphorylated on serine 276. Accessibility to both sites is blocked in unphosphorylated p65 through an intramolecular masking of the N terminus by the C-terminal region of p65. Phosphorylation by PKA both weakens the interaction between the N- and C-terminal regions of p65 and creates an additional site for interaction with CBP/p300. Therefore, PKA regulates the transcriptional activity of NF-kappa B by modulating its interaction with CBP/p300.
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Text Mining Data
NF-kappa B → protein kinase A (PKA): "
The transcriptional activity of
NF-kappa B is
stimulated upon phosphorylation of its p65 subunit on serine 276 by
protein kinase A (PKA)
"
NF-kappa B → PKA: "
Therefore, PKA regulates the transcriptional activity of NF-kappa B by modulating its interaction with CBP/p300
"
NF-kappa B — CBP/p300: "
Therefore, PKA regulates the transcriptional activity of NF-kappa B by modulating its interaction with CBP/p300
"
PKA — CBP/p300: "
Therefore, PKA regulates the transcriptional activity of NF-kappa B by modulating its interaction with CBP/p300
"
Manually curated Databases
-
IRef Hprd Interaction:
RELA
—
PRKACA
(in vitro)
-
IRef Hprd Interaction:
RELA
—
PRKACA
(in vivo)
-
IRef Ophid Interaction:
CREBBP
—
RELA
(aggregation, confirmational text mining)
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA)
→
PKC alpha (PRKCA)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
PKC alpha (PRKCA)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1)
→
IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA)
(modification, activates)
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(modification, activates)
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(modification, activates)
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Evidence: assay, physical interaction
In total, 34 gene pairs are associated to this article in curated databases