◀ Back to EPHB2

CPO — EPHB2

Text-mined interactions from Literome

Bomser et al., J Biochem Mol Toxicol 2000 (MAP Kinase Signaling System) : We find that CP and CPO activate extracellular signal regulated kinases ( ERK 44/42 ) in both wild-type ( CHOK1 ) and human muscarinic receptor expressing Chinese hamster ovary cells ( CHO-M2 ) ... ERK 44/42 activation by CPO is insensitive to the protein kinase A inhibitor H-89, but is completely abolished by the phosphatidylinositol 3-kinase ( P13-K ) inhibitor wortmannin, the protein kinase C ( PKC ) inhibitor GF-109203X, and the mitogen activated extracellular signal regulated protein kinase kinase ( MEK ) inhibitor PD 098059
Bomser et al., Toxicol Appl Pharmacol 2002 : This study tests the hypothesis that diacylglycerol ( DAG ) is the secondary messenger responsible for CPO induced ERK 44/42 activation