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EPHB2 — PPARA
Text-mined interactions from Literome
Kim et al., J Pharmacol Exp Ther 2003
(Neuroblastoma) :
We also found that PPAR-gamma antagonist GW9662 ( 2-chloro-5-nitro-N-phenylbenzamide ) reversed the 15-deoxy-PGJ2 induced cell growth inhibition,
PPAR-gamma expression, and
activation of
ERK2
Lin et al., Cell Signal 2011
(Carcinoma, Non-Small-Cell Lung) :
In addition, activation of P(38) instead of
ERK played a critical role in TGFß induced expression of
PPAR? , which subsequently activated RhoA in H460 cell
Huang et al., FASEB J 2011
:
Exposure to HIV-1 infected monocytes
induced phosphorylation of
ERK1/2 and Akt in hCMEC by 2.5- and 3.6-fold, respectively ; however, these effects were attenuated by overexpression of PPARa or
PPAR? and by silencing of caveolin-1 ( cav-1 )
Stachowska et al., J Agric Food Chem 2011
(MAP Kinase Signaling System) :
PPAR? was phosphorylated mainly by
ERK1/2 , and consequently,
PPAR? phosphorylation was
suppressed mainly by cis-9,trans-11 isomer
Duan et al., J Biol Chem 2012
:
However,
PPAR? activation by ligands or
ERK1/2 inhibitors induced hepatic LDLR expression
Wang et al., PPAR research 2012
:
Leptin treatment also leads to a mild downregulation of PPAR mRNA expression and a significant
MAPK/ERK dependent
PPAR? phosphorylation at serine 112/82
Mahali et al., Biochem Pharmacol 2012
(Diabetes Complications) :
Only mangiferin, a ß-D-glucoside, prevented AGE mediated decrease in
PPAR? activity and
inhibited phosphorylation of
ERK and cytoplasmic translocation of PPAR?
Morgenweck et al., Neuropharmacology 2013
(Ataxia...) :
We conclude that pioglitazone reduces spinal glial and stimulus evoked
p-ERK activation and that
PPAR? activation
blocks the development of and reduces established neuropathic pain