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HMGCR — TNF
Text-mined interactions from Literome
Gallardo et al., Biochem Biophys Res Commun 2003
:
We have examined the
effects of
tumor necrosis factor alpha (TNF alpha) and its second messenger, ceramide, on
HMGCoA reductase , the rate limiting enzyme in the mevalonate pathway
Nübel et al., FASEB J 2004
(Neoplasms) :
As shown by ELISA and FACS analyses,
HMG-CoA reductase inhibitors ( e.g., lovastatin )
impair the
TNF-alpha stimulated increase in E-selectin protein expression
Nishimura et al., Horm Metab Res 2006
(Bacteroidaceae Infections...) :
Although Pg and E. coli LPS had no effect on HMG-CoA reductase gene expression, both
tumor necrosis factor-alpha and interleukin-6 (IL-6), especially IL-6 at low concentration, markedly
up-regulated HMG-CoA reductase gene expression
Mukai et al., Am J Physiol Heart Circ Physiol 2007
:
Simvastatin, a
3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, which is known to activate PI3K/Akt,
blocks TNF-alpha- and insulin induced PAI-1 expression
Park et al., Arch Pharm Res 2008
:
Simvastatin, a
HMG-CoA reductase inhibitor,
suppressed both
tumor necrosis factor (TNF)-alpha- and angiotensin (Ang) II-induced monocyte adhesion to endothelial cells ( an initial step in vascular inflammation ) and reactive oxygen species ( ROS ) production
Araújo et al., Biomed Pharmacother 2010
(Disease Models, Animal...) :
The inhibitory function of atorvastatin on multiple parameters of main components of inflammatory angiogenesis revealed in this study is clearly associated with the modulatory
effects of
HMG-CoA reductase on VEGF,
TNF-alpha and TGF-beta1 production
Hardardóttir et al., Lymphokine Cytokine Res 1994
(Inflammation) :
TNF or IL-1
increased hepatic
HMG CoA reductase mRNA levels by 3.5- and 3-fold, respectively ...
TNF + IL-1
increased HMG CoA reductase mRNA levels by 7-fold
Memon et al., Endocrinology 1993
:
Moreover,
TNF and IL-1 produced a 2.3- and 2.1-fold
increase in hepatic
HMG-CoA reductase activity, respectively