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SPHK1 — TNF
Text-mined interactions from Literome
Xia et al., J Biol Chem 1999
(Arteriosclerosis) :
We now show that HDL profoundly inhibit
TNF stimulated
sphingosine kinase activity in endothelial cells resulting in a decrease in sphingosine 1-phosphate production and adhesion protein expression
Vann et al., J Biol Chem 2002
(Glioma) :
TNF-alpha also
stimulates sphingosine kinase , the enzyme that phosphorylates sphingosine to form sphingosine-1-phosphate ( SPP ), a further metabolite of ceramide
Taha et al., J Biol Chem 2005
:
Tumor necrosis factor induces the loss of
sphingosine kinase-1 by a cathepsin B-dependent mechanism
Mastrandrea et al., Diabetes 2005
:
IL-1beta or
TNF-alpha increased islet
SPHK activity within 15 min to 1 h ; activity remained elevated after 8 h. SPHK2 was the predominant active isoform in INS-1 cells ; little or no SPHK1 activity was detected ... Compared with basal values, IL-1beta and
TNF-alpha induced
increases in
SPHK1a mRNA levels relative to 18S ribosomal RNA in INS-1 cells within 1 h ; relative SPHK2 mRNA levels were unchanged after cytokine treatment ... Thus, IL-1beta and
TNF-alpha induced an early and sustained
increase in
SPHK activity in INS-1 cells and isolated islets, suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines
Billich et al., Cell Signal 2005
:
Using human A549 epithelial lung carcinoma cells as a model system, we observed transient upregulation of
sphingosine kinase type 1 (SPHK1) enzyme activity upon
stimulation with both
TNF-alpha or IL-1beta
Yang et al., J Immunol 2005
:
Consistently, overexpression of dominant negative
SPHK1 increased the production of IL-2,
TNF-alpha , and IFN-gamma in Th1 cells
Bu et al., FASEB J 2006
:
Furthermore, experiments using SphK1 specific siRNA demonstrated that
SphK1 is
required for the
TNF-alpha stimulation of MMP1
Zhi et al., J Cell Physiol 2006
(Inflammation) :
We show that
TNFalpha rapidly
triggers S1P generation and activation of
SPHK
Radeff-Huang et al., J Biol Chem 2007
(Brain Neoplasms...) :
Tumor necrosis factor-alpha (TNF-alpha) has been shown to
activate sphingosine kinase ( SphK ) in a variety of cell types ... Signaling mechanisms through which
SphK mediated the effect of
TNF-alpha on DNA synthesis were then examined
Chandru et al., Gene 2007
:
Dimethylsphingosine, an inhibitor of
sphingosine kinase , partially
inhibited TNF-alpha induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction
Nayak et al., Neuroscience 2010
(Encephalitis...) :
Suppression of
SphK1 by its inhibitor, N, N Dimethylsphingosine ( DMS ), or siRNA
resulted in decreased mRNA expression of
TNF-alpha , IL-1beta, and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia
Alvarez et al., Nature 2010
:
These results also highlight the key
role of
SphK1 and its product S1P in
TNF-alpha signalling and the canonical NF-kappaB activation pathway important in inflammatory, antiapoptotic and immune processes
Gurgui et al., Cell Signal 2010
:
Although our experimental data clearly show the mediatory
role of
sphingosine kinase ( SK ) -derived S1P in the
TNF-alpha and the LPS induced activation of NF-kB, exogenously added S1P failed to trigger this transcription factor
Scherer et al., Stroke 2010
(Hearing Loss) :
TNF-a activated
sphingosine kinase 1 (Sk1) and induced its translocation to the smooth muscle cell membrane