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CEBPB — NOS2
Text-mined interactions from Literome
Gupta et al., Am J Physiol 1999
:
In trans-activation assays, overexpression of
C/EBPbeta stimulated basal
NOS2 promoter activity
Jana et al., J Biol Chem 2001
:
However, CD40 ligation alone induced the activation of only NF-kappaB but not of C/EBPbeta, suggesting that the activation of NF-kappaB alone by CD40 ligation is not sufficient to induce the expression of
iNOS and that the activation of
C/EBPbeta is also
necessary for the expression of iNOS ... Consistently, dominant negative mutants of p65 ( Deltap65 ) and
C/EBPbeta ( DeltaC/EBPbeta )
inhibited the expression of
iNOS in BV-2 microglial cells that were stimulated with the combination of IFN-gamma and CD40 ligand
Teng et al., Circ Res 2002
(Anoxia) :
C/EBP-beta mediates
iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells ... Thus,
C/EBP-beta mediates , at least in part, hypoxia induced
iNOS expression in rPSMs
Liu et al., J Biol Chem 2002
:
Activation of NF-kappaB as well as C/EBPbeta by RSV-tat, stimulation of RSV-tat induced production of NO by the wild type of p65 and C/EBPbeta, and inhibition of RSV-tat induced production of NO by deltap65, a dominant negative mutant of p65, and deltaC/EBPbeta, a dominant negative mutant of C/EBPbeta, suggest that RSV-tat
induces iNOS through the activation of NF-kappaB and
C/EBPbeta
Jana et al., Free Radic Biol Med 2005
:
However, among the three cytokines, only IL-1beta was capable of inducing the activation of CCAAT/enhancer binding proteinbeta ( C/EBPbeta ), suggesting an essential
role of
C/EBPbeta in the expression of
iNOS in astrocytes ... However, the activation of NF-kappaB and
C/EBPbeta was
involved in the induction of
iNOS by IL-1beta as well as by IL-IF
Kim et al., Biochem Biophys Res Commun 2005
:
8-Hydroxyquinoline
inhibits iNOS expression and nitric oxide production by down regulating LPS induced activity of NF-kappaB and
C/EBPbeta in Raw 264.7 cells
Sakitani et al., Genes Cells 1998
:
Synergistic
regulation of inducible
nitric oxide synthase gene by
CCAAT/enhancer binding protein beta and nuclear factor-kappaB in hepatocytes ... These results demonstrate that
C/EBPbeta may
involve iNOS gene expression synergistically with NF-kappaB in primary cultured rat hepatocytes