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CASP3 — TIMP3
Text-mined interactions from Literome
Yuan et al., Amino Acids 2008
(MAP Kinase Signaling System) :
TIMP-3 treatment
induced the expression of Fas and Fasl proteins, and the activation of
caspase-8 and caspase-3
Shen et al., PloS one 2010
:
TIMP-3 overexpression resulted in decreased frequency of B and T lymphocytes and increased frequency of myeloid cells in blood and BM,
increased Lineage negative
Sca-1 ( + ) KIT ( + ) cell proliferation in vivo and in vitro and increased colony forming cell trafficking to blood and spleen
Hojilla et al., PloS one 2011
(Inflammation) :
Here we show that
TIMP3 deficiency
leads to TNF dysregulation, earlier
caspase activation and onset of mitochondrial apoptosis