Gene interactions and pathways from curated databases and text-mining

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CASP3 — TIMP3

Text-mined interactions from Literome

Yuan et al., Amino Acids 2008 (MAP Kinase Signaling System) : TIMP-3 treatment induced the expression of Fas and Fasl proteins, and the activation of caspase-8 and caspase-3
Shen et al., PloS one 2010 : TIMP-3 overexpression resulted in decreased frequency of B and T lymphocytes and increased frequency of myeloid cells in blood and BM, increased Lineage negative Sca-1 ( + ) KIT ( + ) cell proliferation in vivo and in vitro and increased colony forming cell trafficking to blood and spleen
Hojilla et al., PloS one 2011 (Inflammation) : Here we show that TIMP3 deficiency leads to TNF dysregulation, earlier caspase activation and onset of mitochondrial apoptosis