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CHUK — ESR1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated nuclear estrogen receptor alpha network: E2/ERA (dimer)/AIB1 complex (ESR1-NCOA3) → IKK alpha (CHUK) (transcription, activates) Park et al., Mol Cell 2005
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor alpha network: E2/ERA (dimer)/AIB1 complex (ESR1-NCOA3) → IKK alpha (CHUK) (transcription, activates) Park et al., Mol Cell 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor alpha network: E2/ERA (dimer)/AIB1 complex (ESR1-NCOA3) → IKK alpha (CHUK) (transcription, activates) Park et al., Mol Cell 2005
  Evidence: mutant phenotype, physical interaction
• WikiPathways Estrogen signaling pathway: ESR1 → Complex of CHUK-IKBKB-IKBKG (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: CHUK — ESR1 (coimmunoprecipitation) Park et al., Mol Cell 2005
• IRef Bind_translation Interaction: CHUK — ESR1 (experimental interaction detection) Park et al., Mol Cell 2005
• IRef Biogrid Interaction: CHUK — ESR1 (colocalization, imaging technique) Park et al., Mol Cell 2005
• MIPS CORUM IKK-alpha--ER-alpha-AIB1 complex: IKK-alpha--ER-alpha-AIB1 complex complex (CHUK-ESR1-NCOA3) Park et al., Mol Cell 2005
• IRef Corum Interaction: Complex of NCOA3-NCOA3-ESR1-CHUK-CHUK-ESR1 (association, chromatin immunoprecipitation assay) Park et al., Mol Cell 2005
• IRef Hprd Interaction: CHUK — ESR1 (in vivo) Park et al., Mol Cell 2005
• IRef Innatedb Interaction: Complex of ESR1-CCND1-CHUK-NCOA3 (unknown, -) Park et al., Mol Cell 2005
• IRef Innatedb Interaction: CHUK — ESR1 (unknown, -) Park et al., Mol Cell 2005

Text-mined interactions from Literome

Zheng et al., Mol Cell Biol 2005 : Together these data demonstrate that E2-induced SRC-3 phosphorylation is dependent on a direct interaction between SRC-3 and ERalpha and can occur outside of the nucleus
Suen et al., J Biol Chem 1998 : SRC-3 enhanced ERalpha and progesterone receptor stimulated gene transcription in a ligand dependent manner, but stimulation of ERbeta mediated transcription was not observed