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NOS3 — TNF

Text-mined interactions from Literome

Saura et al., J Mol Biol 1999 : We investigated the molecular mechanism for the synergistic induction of inducible nitric oxide synthase transcription by TNF-alpha and IFN-gamma
Sánchez de Miguel et al., J Vasc Res 1999 : In addition, TNF-alpha reduced eNOS mRNA levels and this was prevented by coincubation with cycloheximide
Cain et al., Crit Care Med 1999 (Cardiomyopathies...) : We hypothesized the following : a ) TNF-alpha and IL-1beta directly depress human myocardial function ; b ) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function ; and c ) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide ( NO )
Akama et al., J Biol Chem 2000 : Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha) dependent , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism
Däubener et al., Adv Exp Med Biol 1999 : We were able to show that the IL-1 and TNF-alpha mediated inhibition of IFN-gamma induced IDO activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase
Chung et al., Immunopharmacol Immunotoxicol 2000 : Protein kinase C independent activation of inducible nitric oxide synthase by tumor necrosis factor-alpha in TM4 Sertoli cells
Wang et al., J Biol Chem 2000 : Here we show that eNOS regulates tumor necrosis factor alpha (TNFalpha) through a mechanism dependent on the production of O ( 2 ) and completely independent of NO ... Expression of eNOS in transfected U937 cells increased phorbol 12-myristate 13-acetate induced TNFalpha promoter activity and TNFalpha production
Vann et al., J Biol Chem 2000 : Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-alpha
Yamaoka et al., Arch Dermatol Res 2000 : Ultraviolet B radiation downregulates inducible nitric oxide synthase expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocyte Pam 212 cells
Morikawa et al., Infect Immun 2000 : The differential regulation of cNOS- and iNOS mediated NO production by IFN-gamma, TNF-alpha , and LPS is discussed
Combs et al., J Neurosci 2001 (Alzheimer Disease...) : beta-Amyloid stimulation of microglia and monocytes results in TNFalpha dependent expression of inducible nitric oxide synthase and neuronal apoptosis
González-Fernández et al., Atherosclerosis 2001 : Cerivastatin prevents tumor necrosis factor-alpha induced downregulation of endothelial nitric oxide synthase : role of endothelial cytosolic proteins ... The aim of the present study was to analyze the effect of cerivastatin, a novel HMG CoA reductase inhibitor, on tumor necrosis factor-alpha (TNF-alpha) induced downregulation of eNOS protein expression in bovine aortic endothelial cells ( BAEC ) ... Cerivastatin prevented TNF-alpha induced downregulation of eNOS protein expression in a concentration dependent manner ( 10 ( -8 ) to 10 ( -5 ) M )
Ochoa et al., Ann Surg 2001 (Wounds and Injuries) : In contrast, nitric oxide synthase expression is induced by IL-1, tumor necrosis factor , and gamma interferon, a T-helper 1 cytokine profile
Paludan et al., Eur Cytokine Netw 2001 : Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1
Sekine et al., Endocrinology 2001 : This action of GH may be sufficient to suppress the synergistic induction of inducible nitric oxide synthase by interferon-gamma and TNFalpha , thereby preventing the cytotoxicity to beta-cells
Kawanaka et al., Hepatology 2002 (Hypertension, Portal) : Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway ... In PHT gastric mucosa we studied ( 1 ) eNOS phosphorylation ( at serine 1177 ) required for its activation ; ( 2 ) association of the phosphatidylinositol 3-kinase ( PI 3-kinase ), and its downstream effector Akt, with eNOS ; and, ( 3 ) whether TNF-alpha neutralization affects eNOS phosphorylation and PI 3-kinase-Akt activation ... To determine human relevance, we used human microvascular endothelial cells to examine directly whether TNF-alpha stimulates eNOS phosphorylation via PI 3-kinase ... Furthermore, TNF-alpha stimulated eNOS phosphorylation in human microvascular endothelial cells ... In conclusion, these findings show that in PHT gastric mucosa, TNF-alpha stimulates eNOS phosphorylation at serine 1177 ( required for its activation ) via the PI 3-kinase-Akt signal transduction pathway
Gayle et al., Brain Res Dev Brain Res 2002 (Encephalitis...) : Inhibition of the inducible form of nitric oxide synthase ( iNOS ) by L-NIL did not affect LPS toxicity, but increased the LPS induced levels of both TNF-alpha and IL-1beta
Thomas et al., Pancreas 2002 (Adenocarcinoma...) : Further, inhibition of nitric oxide ( NO ) synthase by L-NAME potentiated the TNF-alpha response, suggesting a protective role for endogenously produced NO in these two cell lines
Aljada et al., Metabolism 2002 : Tumor necrosis factor-alpha inhibits insulin induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells ... Because tumor necrosis factor-alpha (TNF-a ) is proinflammatory and may thus inhibit the action of insulin at the endothelial cell level, we have now investigated whether TNF-a affects ( 1 ) insulin receptor content ; ( 2 ) insulin receptor (IR) autophosphorylation induced by insulin, and ( 3 ) e-NOS expression by the endothelial cells ... TNF-alpha ( 1 to 5 ng/mL ) caused e-NOS inhibition in a dose dependent fashion as measured by Western blotting ... Although the inhibition of IR autophosphorylation by TNF-alpha is known to occur at the adipocyte level, the data on the inhibitory effect of TNF-alpha on insulin induced e-NOS expression and IRP contents are novel
Ribeiro et al., J Urol 2002 (Cystitis...) : The induction of inducible nitric oxide synthase in the urothelium appears to depend on the synergistic effect of IL-1beta and TNF-alpha
Fecker et al., J Invest Dermatol 2002 (Breast Neoplasms...) : Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha , interferon-gamma, and lipopolysaccharide
Barsacchi et al., Mol Pharmacol 2003 : Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha : a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3 ' kinase, and Akt ... We have recently reported that eNOS , expressed in an inducible HeLa Tet-off cell line, is activated by tumor necrosis factor-alpha (TNF-alpha) in a previously undescribed pathway that involves the lipid messenger ceramide ... We report here that eNOS activation in response to TNF-alpha correlated with phosphorylation of Akt at Ser 473 and of eNOS itself at Ser 1179 ... Taken together, these results indicate that eNOS activation by TNF-alpha occurs through sequential activation of neutral sphingomyelinase and of the phosphatidylinositol-3 ' kinase/Akt pathway
Frost et al., Endocrinology 2003 : TNF alpha increased both nitric oxide synthase-II mRNA and protein, and the nitric oxide donor sodium nitroprusside decreased IGF-I mRNA levels in C2C12 cells
Gottstein et al., Br J Nutr 2003 (Arteriosclerosis) : In a macrophage cell line ( RAW 264.7 ) activated with interferon gamma plus lipopolysaccharide, both isoflavones were found to inhibit NO production and tumour necrosis factor alpha (TNF-alpha) secretion dose-dependently, but they did not affect mRNA levels for inducible nitric oxide synthase and cyclo-oxygenase-2
Fonseca et al., Eur J Immunol 2003 (Leishmaniasis, Cutaneous) : TNF-alpha mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis
Paz et al., J Am Coll Cardiol 2003 (Disease Models, Animal...) : Effect of tumor necrosis factor-alpha on endothelial and inducible nitric oxide synthase messenger ribonucleic acid expression and nitric oxide synthesis in ischemic and nonischemic isolated rat heart
Neumann et al., Am J Physiol Lung Cell Mol Physiol 2004 : TNF-alpha induces a decrease in eNOS promoter activity ... Truncated-promoter analysis indicated the response elements ( -370 ) CACCC, ( -231 ) GATA, and ( -186 ) CACCC may regulate the effect of TNF-alpha on the eNOS promoter ... Our data indicate TNF causes a decrease in eNOS promoter activity that may be mediated by GATA-4 and Sp3
Mocellin et al., Clin Cancer Res 2004 (Melanoma...) : We investigated the role of endothelial nitric oxide synthase in determining the tumor-selective activity of TNF
Tanaka et al., Free Radic Biol Med 2005 : Similarly, DEM and CDNB inhibited TNF-alpha induced Akt and eNOS phosphorylation, suggesting that thiol modification is involved in eNOS inductive pathways
Ortega-Gutiérrez et al., FASEB J 2005 (Multiple Sclerosis) : Additionally, in microglial cells, UCM707 decreases the production of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha , interleukin (IL)-1beta, and IL-6 ; reduces nitric oxide levels and inducible nitric oxide synthase expression ; and is able to potentiate the action of a subeffective dose of the endocannabinoid anandamide
de Souza et al., Mol Cell Biochem 2006 : Both TNF-alpha and inosine increased nitrite accumulation and nitric oxide synthase activity ... Erythro-9- ( 2-hydroxy-3-nonyl ) adenine ( EHNA ), an adenosine deaminase inhibitor, abolished the TNF-alpha induced inosine increase, nitrite accumulation and nitric oxide synthase activity
Dekker et al., Blood 2006 : Protein levels for thrombomodulin, endothelial nitric oxide synthase , and plasminogen activator inhibitor type-1 are altered to atheroprotective levels, even in the presence of the inflammatory cytokine TNF-alpha
Seidel et al., Kardiol Pol 2006 (Cardiovascular Diseases) : As for proinflammatory cytokines, both TNF-alpha and IL-1beta substantially down-regulated the eNOS mRNA level ( p < 0.05 )
Elahi et al., Exp Clin Transplant 2006 (Vascular Diseases) : The role of tumor necrosis factor-alpha in mediating pathophysiological activity of inducible nitric oxide synthase during transplant vasculopathy remains contentious
van Thienen et al., Cardiovasc Res 2006 (Atherosclerosis...) : We demonstrate that prolonged shear stress has a potential that is superior to that of statins to induce the KLF2 dependent expression of eNOS and TM, especially in the presence of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha)
Yang et al., Am J Physiol Heart Circ Physiol 2007 : TNF-alpha also induced nitric oxide production through activation of endothelial nitric oxide synthase (eNOS) present in the same membrane compartment
Zamorano-León et al., J Cardiovasc Pharmacol 2006 : TNF-alpha ( 10 ng/mL ) reduced the expression of eNOS protein
Skorokhod et al., Malaria journal 2007 (Malaria) : Malarial pigment haemozoin, IFN-gamma, TNF-alpha , IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Arai et al., Acta Otolaryngol 2008 : Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-alpha in nasal microvascular endothelial cells
De Palma et al., J Neurochem 2008 (Amyotrophic Lateral Sclerosis...) : We found that eNOS , which is endogenously expressed by these cells, was activated by tumour necrosis factor-alpha (TNF-alpha) , a proinflammatory cytokine that plays important roles in ALS2 and several neurodegenerative diseases ... The TNF-alpha dependent eNOS activation occurred through generation, by sphingosine-kinase-1, of sphingosine-1-phosphate, stimulation of its membrane receptors and activation of Akt, as determined using small interference RNA and dominant negative constructs specific for the enzymes and receptors ... eNOS activation by TNF-alpha conferred cytoprotection from excitotoxicity and neurotoxic cues such as reactive oxygen species, endoplasmic reticulum stress, DNA damage, and mutated alsin itself
Henrich et al., Microcirculation 2008 (Disease Models, Animal...) : In the non-parenchymal cell fraction, eNOS gene expression was preserved and gene expression of TNF-alpha was blocked after MDP but not after GdCl ( 3 ) application prior to LPS shock
Yan et al., Circ Res 2008 : Furthermore, adenovirus mediated overexpression of eEF1A1 increased eNOS mRNA instability, whereas knockdown of eEF1A1 substantially attenuated TNF-alpha induced destabilization of eNOS mRNA and downregulation of eNOS expression in HUVECs ... These results indicate that eEF1A1 is a novel eNOS 3'-UTR binding protein that plays a critical role in mediating TNF-alpha induced decrease in eNOS mRNA stability
Eisenreich et al., Biol Chem 2008 : We found that inhibition of DNA topoisomerase I, but not Cdc2-like kinases, prevents the TNF-alpha induced increase in eNOS isoform expression and NO reduction in HUVEC ... Our results demonstrate, for the first time, that DNA topoisomerase I but not Cdc2-like kinases serves as an important regulator of the differential eNOS isoform expression in endothelial cells, thereby modulating the TNF-alpha induced eNOS activity switch
Xu et al., Stem Cells 2009 : C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1, inducible nitric oxide synthase , and CCL5 in response to concomitant IFNgamma and TNFalpha
Ding et al., J Immunol 2009 (Shock, Septic...) : TNF-alpha knockout mice prevented LPS induced eNOS down-regulation
Jiang et al., Cardiovasc Res 2010 : HIV gp120 and TNF-alpha synergistically reduce eNOS expression and cause endothelial dysfunction in both porcine coronary arteries and HCAECs
Tsou et al., J Cell Biochem 2010 : Integrin linked kinase is involved in TNF-alpha induced inducible nitric-oxide synthase expression in myoblasts
Harada et al., Cell Death Differ 2010 (Disease Models, Animal...) : Tumor necrosis factor (TNF) induced activation of p38 MAPK and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells
Zemse et al., Am J Physiol Heart Circ Physiol 2010 : Western blot analysis showed that endothelial nitric oxide synthase (eNOS) expression was reduced by TNF-a in in vitro and in vivo experiments, whereas IL-10 restored the eNOS expression
Zhang et al., Am J Physiol Heart Circ Physiol 2010 (Diabetes Mellitus, Type 2...) : This improvement is due to the role of resveratrol in inhibiting TNF-a induced NF-?B activation, therefore subsequently inhibiting the expression and activation of NAD ( P ) H oxidase and iNOS as well as increasing eNOS expression in type 2 diabetes
Zhao et al., Mol Biol Rep 2012 (Glomerulonephritis) : Aldose reductase regulates TNF-a induced inducible nitric oxide synthase expression in human mesangial cells
Cheung et al., J Clin Invest 2011 (Disease Models, Animal...) : Surprisingly, MDL-1 induced NO and TNF-a production required eNOS but not iNOS
Ramseyer et al., Hypertension 2012 : However, the effects of TNF-a on THAL NOS3 and the signaling cascade are unknown ... Inhibition of Rho GTPase with 0.05 µg/mL of C3 exoenzyme blocked TNF-a induced reductions in NOS3 expression by 30 ± 8 % ( P < 0.02 ) ... Inhibition of ROCK with 10 µmol/L of H-1152 blocked TNF-a induced decreases in NOS3 expression by 66 ± 15 % ( P < 0.001 ) ... Myosin light chain kinase, NO, protein kinase C, mitogen activated kinase kinase, c-Jun amino terminal kinases, and Rac-1 were also not involved in TNF-a induced decreases in NOS3 expression
Pan et al., Respir Res 2012 (Acute Lung Injury...) : Compared with MV group, LV group significantly reduced LPS induced expression of ET-1 level ( 113.79 ± 7.33pg/mL vs. 152.52 ± 12.75pg/mL, P < 0.05 ) and TNF-a ( 3305.09 ± 334.29pg/mL vs.4144.07 ± 608.21pg/mL, P < 0.05 ), increased the expression of eNOS ( IOD : 15032.05 ± 5925.07 vs. 11454.32 ± 6035.47, P < 0.05 )
Sun et al., Hypertension 2012 : Inhibition of miR-155 reversed tumor necrosis factor-a induced downregulation of eNOS expression and impairment of endothelium dependent vasorelaxation ... Moreover, we observed that simvastatin attenuated tumor necrosis factor-a induced upregulation of miR-155 and ameliorated the effects of tumor necrosis factor-a on eNOS expression and endothelium dependent vasodilation
Wang et al., Sleep Med 2013 (Anoxia...) : NF-?B p50 gene deletion blocked NF-?B activation, inhibited TNF-a expression, prevented eNOS down-regulation and reversed the impaired endothelium dependent vasodepressor response induced by CIH
Arita et al., Invest Ophthalmol Vis Sci 2013 (Diabetic Angiopathies...) : TNF-a induced intercellular adhesion molecule-1 ( ICAM-1 ) and endothelial nitric oxide synthase (eNOS) phosphorylation were measured with and without ROCK inhibition by fasudil or ROCK-specific small interfering RNA ( siRNA )
Ning et al., PloS one 2013 (Inflammation...) : In addition, NaHS treatment prevented the increase of nitric oxide, Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible nitric oxide synthase activation induced by TNF-a
Yamada et al., Biochem Biophys Res Commun 1993 : Nitric oxide and nitric oxide synthase mRNA induction in mouse islet cells by interferon-gamma plus tumor necrosis factor-alpha
Koide et al., Hypertension 1994 : These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Marumo et al., Jpn J Pharmacol 1993 : Dexamethasone inhibits nitric oxide synthase mRNA induction by interleukin-1 alpha and tumor necrosis factor-alpha in vascular smooth muscle cells
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Yoshizumi et al., Circ Res 1993 : TNF-alpha markedly reduced cNOS mRNA levels in HUVECs in a dose- and time dependent manner ... As little as 0.1 ng/mL TNF-alpha reduced cNOS mRNA levels by 50 % ... TNF induced reductions in cNOS mRNA levels may have an important effect on impaired endothelium mediated vasorelaxation in atherosclerosis
Xie et al., Am Rev Respir Dis 1993 : Tumor necrosis factor alpha (TNF alpha) increases nitric oxide ( NO ) synthase in vascular endothelium, but it inhibits endothelium dependent relaxation ( EDR ) of vascular smooth muscle
Förstermann et al., Naunyn Schmiedebergs Arch Pharmacol 1995 : TNF-alpha reduces the expression of NOS III by a post-transcriptional mechanism destabilizing the mRNA
Dunger et al., Diabetes 1996 : Used alone or in combination, TNF and IFN significantly enhanced the activity of inducible nitric oxide synthase as determined by measuring the conversion of 14C labeled arginine to 14C labeled citrulline and nitric oxide
Geng et al., Cancer Res 1996 (Leukemia, Erythroblastic, Acute) : Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha
Manfield et al., Inflamm Res 1996 : Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both nitric oxide synthase and cyclooxygenase activities were induced by the inflammatory mediators, lipopolysaccharide, and interleukin-1 beta or tumor necrosis factor-alpha
Simper et al., Cardiovasc Res 1995 (Shock, Septic) : Experimental and clinical evidence suggests that tumour necrosis factor-alpha (TNF) induces the expression of vascular nitric oxide ( NO ) synthase within hours and that NO released from smooth muscle cells could be involved in the pathogenesis of septic shock
Asano et al., Nihon Kyobu Shikkan Gakkai Zasshi 1995 : All epithelial cells exhibited constitutive NOS activity that was calcium dependent, and inducible, lesser calcium dependent activity in the presence of interferon-gamma, interleukin-1 beta, tumor necrosis factor-alpha , and lipopolysaccharide
Romero et al., Am J Physiol 1996 : Roles of IL-1 and TNF-alpha in endotoxin induced activation of nitric oxide synthase in cultured rat brain cells
Zwaveling et al., Crit Care Med 1996 (Neoplasms...) : The hypothesis that in humans, TNF-alpha induces vasodilation and shock through activation of inducible nitric-oxide synthase and subsequent formation of excessive quantities of nitric oxide is not substantiated by our results
Ogura et al., Biochem Biophys Res Commun 1997 (Neuroblastoma) : TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin
Obregón et al., Eur J Neurosci 1997 (Brain Neoplasms...) : The isoform of the nitric oxide synthase induced in human neuroblastoma cells by TNF-alpha treatment was identified enzymatically as isoform II by Western blotting and by the polymerase chain reaction
Gansauge et al., FEBS Lett 1997 : Induction of inducible nitric oxide synthase by tumor necrosis factor-alpha , interferon-gamma and interleukin-1beta inhibited cell proliferation and led to a G1 arrest
Ohta et al., Hepatology 1998 (Hypertension, Portal) : These results suggest that TNF-alpha may regulate NOS3 expression in the portal hypertensive stomach and that anti-TNF-alpha treatment may ameliorate the pathophysiological abnormalities of portal hypertensive gastric mucosa
Hoffmann et al., Int Arch Allergy Immunol 1998 : Single stimulation of smooth muscle cells with either neopterin or tumor necrosis factor-alpha caused inducible nitric oxide synthase gene expression and nitric oxide production
Hoffmann et al., Eur J Pharmacol 1998 : We show that G-CSF suppresses interferon-gamma/tumor necrosis factor-alpha (TNF-alpha) induced inducible nitric oxide synthase gene expression detected as inducible nitric oxide synthase cDNA ( cDNA concentration was 633 +/- 38 amol/microg total RNA following 24 h incubation with 100 U/ml interferon-gamma/500 U/ml TNF-alpha, and 440 +/- 14 amol/microg total RNA following 24 h incubation with 250 U/ml G-CSF +/- 100 U/ml interferon-gamma/500 U/ml TNF-alpha, respectively )
Ookawauchi et al., J Hepatol 1998 : The effect of tumor necrosis factor-alpha and interferon-gamma on L-arginine transport, mRNA expression of cationic amino acid transporter and inducible nitric oxide synthase , and nitric oxide production of stellate cells was assessed ... In transformed hepatic stellate cells, tumor necrosis factor-alpha and interferon-gamma have a crucial role in nitric oxide production, and extracellular L-arginine transport and inducible nitric oxide synthase expression are regulated in a differential cytokine-specific manner