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AKT3 — FASN

Text-mined interactions from Literome

Sabbisetti et al., PloS one 2009 (Carcinoma, Squamous Cell) : FASN induced AKT phosphorylation and a significant reduction in cell viability was observed when FASN overexpressing SCC9 cells were treated with an AKT inhibitor after p63 knockdown, indicating that AKT plays a major role in FASN mediated survival
Lin et al., J Agric Food Chem 2010 (Breast Neoplasms) : The use of Akt-overexpression revealed that the modulation of Akt and mTOR was required for osthole induced FASN suppression
Uddin et al., Mol Med 2011 (Neoplasms, Glandular and Epithelial...) : Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin induced apoptosis ... FASN inhibition caused downregulation of activated AKT and its downstream targets
Lee et al., Phytother Res 2013 (Breast Neoplasms) : The use of pharmacological inhibitors revealed that the modulation of AKT , mTOR, and JNK phosphorylation required synergistic amentoflavone induced FASN inhibition and HER2 activation in SKBR3 cells