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GPC3 — WNT11

Text-mined interactions from Literome

Capurro et al., J Biol Chem 2005 (Carcinoma, Hepatocellular...) : It has been reported that processing by a convertase is required for GPC3 activity during convergent extension in zebrafish embryos, for GPC3 induced regulation of Wnt signaling, and for the binding of GPC3 to Wnt5a
Traister et al., Biochem J 2008 : Finally, by using a cellular system in which GPC3 ( glypican-3 ) stimulates Wnt signalling, we show that Notum can act as a negative regulator of this growth factor
Buchanan et al., Breast Cancer Res Treat 2010 (Adenocarcinoma...) : We demonstrated that GPC3 inhibits canonical Wnt signaling, as well as it activates non canonical pathway
Zittermann et al., Int J Cancer 2010 (Carcinoma, Hepatocellular...) : Because GPC3 binds with high affinity to Wnts, and its growth promoting activity requires attachment to the cell membrane, we have hypothesized that a mutated GPC3 lacking the GPI anchoring domain ( sGPC3 ) will block Wnt signaling and inhibit the growth of Wnt dependent tumors
Lai et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Together, these findings identify a novel mechanism mediating the oncogenic function of SULF2 in HCC that includes GPC3 mediated activation of Wnt signaling via the Wnt3a/glycogen synthase kinase 3 beta axis