Yusoff et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
hSpry2 had no inhibitory effect on either the JNK or the p38 pathway and displayed no inhibition of FRS2 phosphorylation, Akt activation , and Ras activation
Mori et al., J Biol Chem 2008
:
Nevertheless, R50E induced phosphorylation of FGFR1 and FRS2alpha and activation of AKT and ERK1/2