Gene interactions and pathways from curated databases and text-mining

◀ Back to JUN

ABCB1 — JUN

Text-mined interactions from Literome

Ratnasinghe et al., Anticancer Res 2001 (Breast Neoplasms) : We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor c-Jun , which in turn, induces the expression of MDR1/Pgp170
Hatle et al., Mol Cell Biol 2007 (Breast Neoplasms) : The induction of ABCB1 gene expression is mediated by increased levels of c-Jun due to an impaired degradation of this transcription factor in the absence of MCJ ... Thus, MCJ is required in these cells to prevent c-Jun mediated expression of ABCB1 and maintain drug response
Roy et al., Cancer Chemother Pharmacol 2010 (Carcinoma, Hepatocellular...) : Further studies revealed the involvement of AP-1 in the celecoxib induced downregulation of MDR1 expression
Takano et al., Biochem Pharmacol 2010 (Carcinoma, Renal Cell...) : Moreover, increased transcription activity of c-Jun by the JNK activation contributed to the down-regulation of MDR1 , thus indicating a central role of JNK signalling to suppress P-gp level in 5-Aza treated Caki-1 cells
Nishanth et al., Eur J Pharmacol 2010 (Carcinoma, Hepatocellular...) : Further studies reveal the involvement of NF-?B and AP-1 in the C-PC induced down regulation of MDR1
Fang et al., Anat Rec (Hoboken) 2012 (Carcinoma, Hepatocellular...) : Our results demonstrated that mda-7/IL-24 could restore the drug sensitivity through the downregulation of MDR1 , MRP1, and LRP expression, as well as the transcriptional activation of AP-1 and NF-?B and effectively reverse MDR
Xia et al., J Biol Chem 2013 (Mammary Neoplasms, Animal) : Activated c-Jun bound to the promoter regions of the MDR1 gene and promoted the expression of MDR1
Choi et al., Evidence-based complementary and alternative medicine : eCAM 2013 : Consistently, overexpression of JNK1, c-Jun , or c-Fos inhibited YB-1 dependent MDR1 expression and reduced viabilities in MCF-7/Dox cells