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ADAM17 — NOTCH3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Brou et al., Mol Cell 2000
:
A novel proteolytic cleavage
involved in
Notch signaling : the role of the disintegrin-metalloprotease
TACE
Gupta-Rossi et al., J Cell Biol 2004
:
Activation of mammalian
Notch receptor by its ligands
induces TNFalpha converting enzyme dependent ectodomain shedding, followed by intramembrane proteolysis due to presenilin ( PS ) -dependent gamma-secretase activity
Huovila et al., Trends Biochem Sci 2005
:
The recent studies have also begun to elucidate the substrate specificity and the mechanisms that control
ADAM mediated shedding events that regulate, for example, growth-factor and
Notch signalling, and the processing of the amyloid precursor protein
Dyczynska et al., J Biol Chem 2007
:
Our findings expand the
role of
ADAM proteins in the regulation of
Notch signaling
Zolkiewska et al., Cell Mol Life Sci 2008
:
ADAM mediated cleavage of
Notch represents the first step in regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway
Delwig et al., Cell Mol Life Sci 2008
:
Kuz and
TACE can
activate Notch independent of ligand ... In contrast,
TACE , which is elevated in expression in the developing Drosophila nervous system, can efficiently
activate Notch in a ligand independent manner
Murthy et al., Immunity 2012
(Inflammation) :
Notch activation by the metalloproteinase
ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis