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ADORA1 — MAPK14

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK14 → ADORA1 (increases, ADORA1 Activity, MAPK14 Activity) Liu et al., Am J Physiol Heart Circ Physiol 2003*
  Evidence: N6-cyclopentyladenosine (CPA; an adenosine A1 receptor agonist)-induced PP2a translocation was blocked by p38 MAPK inhibition but not by JNK inhibition. CPA increased phosphorylation of p38 MAPK, and this effect was abolished by pertussis toxin and inhibitors of the cGMP pathway

Text-mined interactions from Literome

Robinson et al., Eur J Pharmacol 2001 : Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT ( 1 ) MF-2 cells ... Furthermore, adenosine A(1) receptor mediated increases in p42/p44 MAPK were sensitive to the MAPK kinase 1 inhibitor PD 98059 ( 2'-amino-3'-methoxyflavone ), whereas p38 MAPK responses were blocked by the p38 MAPK inhibitor SB 203580 ( 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ) ... Furthermore, adenosine A(1) receptor mediated increases in p42/p44 MAPK were sensitive to the MAPK kinase 1 inhibitor PD 98059 ( 2'-amino-3'-methoxyflavone ), whereas p38 MAPK responses were blocked by the p38 MAPK inhibitor SB 203580 ( 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ) ... Furthermore, the protein kinase C inhibitors Ro 31-8220 ( 3- [ 1- [ 3- ( 2-isothioureido ) propyl ] indol-3-yl ] -4- ( 1-methylindol-3-yl ) -3-pyrrolin-2,5-dione ), chelerythrine and GF 109203X ( 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ) were without effect on adenosine A(1) receptor induced p42/p44 MAPK phosphorylation ... Finally, adenosine A(1) receptor stimulation in DDT ( 1 ) MF-2 cells also activated p38 MAPK but not JNK via a pertussis toxin-sensitive pathway ... Finally, adenosine A(1) receptor stimulation in DDT ( 1 ) MF-2 cells also activated p38 MAPK but not JNK via a pertussis toxin-sensitive pathway
Lasley et al., Am J Physiol Heart Circ Physiol 2005 (Myocardial Infarction) : Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent
Ballard-Croft et al., Am J Physiol Heart Circ Physiol 2008 (MAP Kinase Signaling System) : However, the adenosine A(1) receptor mediated MAPK activation does not involve ROS formation