Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Huang et al., Cardiovasc Drugs Ther 2011 (Disease Models, Animal...) : LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor ( Rp-cAMPS ) or Akt-inhibitor ( AKT 1/2 kinase inhibitor )
Hanrahan et al., Cancer Discov 2012 (Cystadenocarcinoma, Serous...) : Inhibition of AKT1 caused growth arrest in a subset of ovarian cell lines, but not in those with AKT3 expression, which required pan-AKT inhibition
Tokuda et al., Hum Mol Genet 2011 (Disease Susceptibility...) : An in vitro kinase assay revealed that Akt3 ( Nmf350 ) confers higher enzymatic activity, suggesting that Akt3 ( Nmf350 ) might enhance AKT signaling in the brain
Peng et al., Genes Dev 2003 (Abnormalities, Multiple...) : Specifically, Akt1 and Akt2 are required for the induced expression of PPARgamma, the master regulator of adipogenesis, establishing a new essential role for Akt in adipocyte differentiation ... These functions of Akt were uncovered despite the observed lower level of Akt activity mediated by Akt3 in Akt1/Akt2 DKO cells, suggesting that a critical threshold level of Akt activity is required to maintain normal cell proliferation, growth, and differentiation