Gene interactions and pathways from curated databases and text-mining

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ANP32A — PPP2R1A

Text-mined interactions from Literome

Habrukowich et al., J Biol Chem 2010 : Suppression of ANP32A with siRNA enhanced basal and DMS activated PP2A activity suggesting that the sphingoid base binds to and relieves the inhibitory action of ANP32A on the PP2A complex ... Indeed, DMS relieved the ANP32A mediated inhibition of PP2A enzyme complex in vitro
Sánchez et al., Hum Mol Genet 2013 (Spinocerebellar Ataxias) : We previously showed that the mutant ataxin-1 interacts with Anp32a , a potent and selective PP2A inhibitor , suggesting a role of PP2A in SCA1 ... In contrast, mutant Atxn1 induces a decrease in Y307-phosphorylation in Pp2a-c, known to enhance its activity, while reducing Pp2a-b expression and inhibiting Anp32a levels