Gene interactions and pathways from curated databases and text-mining

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ANXA1 — IL6

Text-mined interactions from Literome

de Coupade et al., Am J Pathol 2001 (Endotoxemia) : Using an extra-hepatic system, we showed that interleukin (IL)-6 regulates ANXA1 expression at the transcriptional level
Warne et al., Am J Physiol Endocrinol Metab 2006 (Body Weight) : Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue
Yang et al., J Immunol 2006 : Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1
Tang et al., PloS one 2011 : The results show that Annexin A1 can negatively regulate phosphorylation of p38 and release of IL-1ß, IL-6 and TNF-a in THP-1 cells following propofol intervention and lipopolysaccharide (LPS) stimulation ... Our results clearly indicate that propofol can up-regulate Annexin A1 to inhibit the phosphorylation level of p38 and release of IL-1ß, IL-6 and TNF-a, so as to inhibit inflammatory response
Yang et al., J Immunol 2013 (Arthritis, Experimental...) : Similarly, experiments using AnxA1 ( -/- ) OT-II CD4 ( + ) T cells demonstrated that the absence of AnxA1 in T cells was sufficient to induce increased Ag-specific CD4 ( + ) T cell proliferation in vivo, augment T cell production of IFN-?, IL-17, TNF, and IL-6 , and increase Akt, ERK, and p38 activation
Solito et al., Cell Growth Differ 1998 (Adenocarcinoma...) : Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549 : involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1
Solito et al., Cytokine 1998 (Adenocarcinoma) : IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein