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ANXA1 — IL6
Text-mined interactions from Literome
de Coupade et al., Am J Pathol 2001
(Endotoxemia) :
Using an extra-hepatic system, we showed that
interleukin (IL)-6 regulates
ANXA1 expression at the transcriptional level
Warne et al., Am J Physiol Endocrinol Metab 2006
(Body Weight) :
Gene deletion reveals
roles for
annexin A1 in the regulation of lipolysis and
IL-6 release in epididymal adipose tissue
Yang et al., J Immunol 2006
:
Annexin 1 negatively
regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1
Tang et al., PloS one 2011
:
The results show that
Annexin A1 can negatively
regulate phosphorylation of p38 and release of IL-1ß,
IL-6 and TNF-a in THP-1 cells following propofol intervention and lipopolysaccharide (LPS) stimulation ... Our results clearly indicate that propofol can up-regulate
Annexin A1 to
inhibit the phosphorylation level of p38 and release of IL-1ß,
IL-6 and TNF-a, so as to inhibit inflammatory response
Yang et al., J Immunol 2013
(Arthritis, Experimental...) :
Similarly, experiments using AnxA1 ( -/- ) OT-II CD4 ( + ) T cells demonstrated that the absence of
AnxA1 in T cells was sufficient to induce increased Ag-specific CD4 ( + ) T cell proliferation in vivo,
augment T cell production of IFN-?, IL-17, TNF, and
IL-6 , and increase Akt, ERK, and p38 activation
Solito et al., Cell Growth Differ 1998
(Adenocarcinoma...) :
Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549 :
involvement of nuclear factor
interleukin 6 in phorbol ester induction of
annexin 1
Solito et al., Cytokine 1998
(Adenocarcinoma) :
IL-6 stimulates
annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein