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APC — IL12A

Text-mined interactions from Literome

Bianchi et al., J Immunol 1999 : We also explore the possibility that the IL-12 resulting from CD40 ligation directly affects the APC function of DC, mediating or contributing to the adjuvant effect of CD40 ligation
Yang et al., Parasite Immunol 1999 (Granuloma) : IL-12 activity was detected in the culture supernatant of T clones stimulated with SEA in the presence of APC ( antigen presenting cells )
Ito et al., J Immunol 2000 (Leukemia, Radiation-Induced...) : Activation of APC via CD40-CD40 ligand pathway induces up-regulation of costimulatory molecules such as B7 and production of IL-12
Fukao et al., J Immunol 2001 : Autocrine activation of APC by IL-12 has recently been revealed ; we demonstrate here that inducible expression of Stat4 in APC is central to this process
Schmidt et al., J Immunol 2002 : IL-12 supports responses when IL-12Rbeta1-deficient mice are used as recipients for the adoptively transferred CD8 T cells, demonstrating that the IL-12 is acting directly on the T cells rather than on host APC
Muraille et al., J Immunol 2003 (Genetic Predisposition to Disease...) : Toll-like receptors recognize pathogen associated molecular patterns and are crucially implicated in the induction of IL-12 secretion by APC
Xin et al., Mol Immunol 2008 (Leishmaniasis, Cutaneous) : La amastigote infected DCs were less mature and less potent antigen presenting cells (APC) than their promastigote infected counterparts, as judged by the lower expression of CD40 and CD83, suppressed cytokine expression ( IL-12p40 and IL-10 ), reduced effectiveness for priming CD4+ T cells from naïve or infected mice
Kim et al., Int Immunol 2009 : gamma-PGA induced the expression of IL-12p40 , CD80 and CD86 in dendritic cells ( DC ) and macrophages in a Toll-like receptor-4 dependent manner, and the effect of gamma-PGA on T ( h ) 1/T ( h ) 2 development was dependent on the presence of antigen presenting cells (APC)
Stuber et al., J Exp Med 1996 (Colitis...) : In conclusion, we demonstrated that the CD40L-CD40 interaction is crucial for the in vivo priming of Th1 T cells via the stimulation of IL-12 secretion by antigen presenting cells (APC)
Maruo et al., J Immunol 1997 : These results indicate that CD40L expressed on activated T cells induces APC to produce IL-12 through CD40/CD40L interaction, but this pathway is competitively inhibited by CD40+ B cells incapable of producing IL-12 upon stimulation with CD40L
Krakowski et al., Eur J Immunol 1997 (Encephalomyelitis, Autoimmune, Experimental) : We have thus shown that a Th1 cytokine bias within the CNS can be induced by CNS APC , and that IL-12 is up-regulated in microglial cells within the CNS of mice with EAE
Morein et al., Dev Biol Stand 1998 : Further, iscoms induce APC to produce IL-1, IL-6 and IL-12 and a TH1 type of response with enhanced IL-2 and IFN-gamma production