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APLP1 — APP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: Complex of APLP2-APLP1-APP (anti bait coimmunoprecipitation) Wang et al., Proc Natl Acad Sci U S A 2007*
• IRef Intact Interaction: APLP1 — APP (physical association, anti tag coimmunoprecipitation) Soba et al., EMBO J 2005*
• IRef Intact Interaction: APLP1 — APP (direct interaction, anti tag coimmunoprecipitation) Soba et al., EMBO J 2005*

Text-mined interactions from Literome

Bayer et al., Mol Psychiatry 1999 (Alzheimer Disease) : In normal adult brain APP , APLP1 and APLP2 are involved in synaptic processes important for memory function
Neumann et al., J Biol Chem 2006 : In LRP-deficient cells APLP1 no longer induced APP shedding, suggesting that in wild-type cells APLP1 interferes with the LRP dependent endocytosis of APP and there by increases APP alpha-cleavage
Beckman et al., Neurosci Lett 1997 (Brain Neoplasms...) : RA induced a 2- to 3-fold increase in the gene expression of both APLP2 and APP , whereas the increase in APLP1 mRNA expression was significantly higher