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AR — IL6

Text-mined interactions from Literome

Chen et al., Cancer Res 2000 (Disease Progression...) : Interleukin 6 activates androgen receptor mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells
Lin et al., Clin Cancer Res 2001 (Prostatic Neoplasms) : Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression
Godoy-Tundidor et al., Clin Cancer Res 2002 (Prostatic Neoplasms) : Interleukin-6 (IL-6) , a proinflammatory cytokine the serum andtissue levels of which are elevated in prostate cancer patients, activates the androgen receptor (AR) in a ligand independent and synergistic manner
Ueda et al., J Biol Chem 2002 (MAP Kinase Signaling System...) : Ligand independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells ... The androgen receptor (AR) can be activated in the absence of androgens by interleukin-6 (IL-6) in human prostate cancer cells
Culig et al., Mol Cell Endocrinol 2002 (Prostatic Neoplasms) : Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth
Lee et al., Clin Cancer Res 2003 (Disease Progression...) : The effects of IL-6 on androgen receptor activity was determined by Northern blots and gel shift assays ... IL-6 enhances androgen receptor DNA binding activity and nuclear translocation
Yang et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System...) : Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
Kim et al., Oncogene 2004 (Prostatic Neoplasms) : Synergism of cytoplasmic kinases in IL6 induced ligand independent activation of androgen receptor in prostate cancer cells
Lu et al., Clin Exp Metastasis 2004 (Prostatic Neoplasms) : Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6 mediated activation of the androgen receptor
George et al., Clin Cancer Res 2005 (Adenocarcinoma...) : Interleukin-6 signaling can activate androgen receptor in a ligand independent manner and may play an important functional role in hormone-refractory prostate cancer ( HRCaP ) progression and patient survival
Gazi et al., Clin Chim Acta 2007 (Prostatic Neoplasms) : Sodium selenite inhibits interleukin-6 mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun
Aaronson et al., Mol Cell Endocrinol 2007 (Prostatic Neoplasms) : Increasing the protein levels of the signal transducer and activator of transcription 3 ( Stat3 ) led to Stat3-androgen receptor (AR) complex formation in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) stimulation
Wang et al., Cancer Biol Ther 2007 (Carcinoma...) : The effect of IL-6 and IL-8 on cell growth and androgen receptor (AR) expression was also analyzed
Neuwirt et al., Endocr Relat Cancer 2007 (Prostatic Neoplasms) : Taken together with previous findings showing androgen receptor activation by IL-6 , our results imply that androgen and cytokine signalling pathways interact at multiple levels in prostate cancer
Malinowska et al., Endocr Relat Cancer 2009 (Prostatic Neoplasms) : The effect of IL-6 on stimulation of androgen receptor activity in MDA PCa 2b cells was lower than that of androgen, comparable with findings reported by other researchers ... Taken together, data in the present study demonstrate that IL-6 may cause growth of androgen receptor positive tumours in vitro and in vivo through activation of the androgen receptor
Culig et al., Mol Cell Endocrinol 2012 (Prostatic Neoplasms) : IL-6 activation of androgen receptor (AR) may contribute to progression of a subgroup of prostate cancers