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AR — JUN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AR → JUN (decreases, JUN Activity, AR Activity)
  Evidence: proto-oncoprotein c-jun was increased by DHA treatment. A transient transfection found that forced expression of c-jun inhibited AR transactivation activity.
• NCI Pathway Database Regulation of Androgen receptor activity: JUN (JUN) → AR/T-DHT complex (AR) (transcription, activates) Sato et al., J Biol Chem 1997*
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AR — JUN (physical association, affinity chromatography technology) Sato et al., J Biol Chem 1997*
• IRef Dip Interaction: AR — JUN (physical association, biochemical) Bubulya et al., J Biol Chem 1996*
• IRef Dip Interaction: AR — JUN (physical association, coimmunoprecipitation) Sato et al., J Biol Chem 1997*
• IRef Hprd Interaction: AR — JUN (in vivo) Bubulya et al., J Biol Chem 1996*, Sato et al., J Biol Chem 1997*
• IRef Hprd Interaction: AR — JUN (in vitro) Bubulya et al., J Biol Chem 1996*, Sato et al., J Biol Chem 1997*
• IRef Hprd Interaction: AR — JUN (two hybrid) Bubulya et al., J Biol Chem 1996*, Sato et al., J Biol Chem 1997*
• IRef Ophid Interaction: AR — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Grierson et al., Neurosci Lett 1999 (Muscular Disorders, Atrophic) : Here we show that the size of this polyglutamine tract influences both c-Jun regulation of androgen receptor mediated transcription and androgen receptor regulation of c-Jun activity
Ikezoe et al., Br J Cancer 2004 (Prostatic Neoplasms) : A previous study showed that c-Jun/AP-1 blocked androgen receptor (AR) signaling by inhibiting AR binding to AR response elements ( AREs ) of target genes including prostate-specific antigen (PSA)
Yuan et al., Cancer Lett 2004 (Prostatic Neoplasms) : Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells
Church et al., Prostate 2005 (Prostatic Neoplasms) : Induction of AP-1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells ... Effects of androgen activated androgen receptor on AP-1 activity were determined in the LNCaP human prostate carcinoma cell model ... Activation of androgen receptor by androgen induces changes in AP-1 activity and AP-1 factor DNA binding that may contribute significantly to androgen induced changes in prostate cancer cell growth
Yuan et al., Mol Cell Biochem 2010 (Prostatic Neoplasms) : We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin mediated downregulation of AR activity