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ARSA — NFKB1

Text-mined interactions from Literome

Liptay et al., Br J Pharmacol 1999 : 4. In contrast, 5ASA and sulfapyridine neither inhibit NF-kappaB/Rel activation nor induce apoptosis in T-lymphocytes at doses up to 5.0 mM ... 5. These results demonstrate that sulfasalazine, but not 5ASA or sulfapyridine, strongly inhibits NF-kappaB activation and potently induces apoptosis in T-lymphocytes
Yoo et al., Am J Physiol Lung Cell Mol Physiol 2001 (Pneumonia) : ASA inhibited TNF-alpha induced activation of NF-kappa B by preventing phosphorylation and subsequent degradation of I kappa B-alpha in a prostanoid independent manner
Cianferoni et al., Blood 2001 : The inhibitory effect of ASA on IL-4 transcription was not mediated by decreased nuclear expression of the known salicylate target nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of, but not overlapping, the NF of activated T cells- and NF-kappaB binding P1 element
Cai et al., Zhonghua Jie He He Hu Xi Za Zhi 1999 : LPS might activate NF-kappa B in the PIMs, and induce the increase of transcription and expression of TNF-alpha gene ; Both DEX and ASA could inhibit the activation of NF-kappa B and reduce the release of TNF-alpha
Eisele et al., J Cardiovasc Pharmacol 2004 : LDL induced activation of the transcription factor NF-kappaB was inhibited by ASA , and ferritin protein was increased when endothelial cells were incubated with this drug
Mortaz et al., Biochem Pharmacol 2005 : Concomitantly, ASA inhibited nuclear factor (NF)-kappaB activity, as well as the phosphorylation and breakdown of the inhibitory protein IkappaB-alpha ... We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkappaB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkappaB-alpha, activation of NF-kappaB , and transcription of proinflammatory cytokines
Habens et al., Apoptosis 2005 (Cell Transformation, Viral...) : SFZ, but not 5-ASA or SPY, inhibits activation of NF-kB
Jancso et al., J Cardiovasc Pharmacol 2005 (Arrhythmias, Cardiac...) : This study investigated the effect of ASA on the late phase of ischemic preconditioning ( PC ) against myocardial infarction and on the activation of NF-kappaB in the preconditioned myocardium
Kim et al., J Biol Chem 2005 (Colonic Neoplasms...) : Biochemical analysis revealed that ASA inhibited NF-kappaB activity, which is known to regulate BCL-2 gene expression, by dephosphorylating IkappaB-alpha and inhibiting IKKbeta activity but not by affecting the HER-2/neu phosphatidylinositol 3-kinase-Akt signal pathway
Redlak et al., J Surg Res 2008 (Stomach Neoplasms) : The aim of this study was to investigate the effect of DC and ASA on NF-kappaB signaling, and determine its role in programmed cell death in a human gastric carcinoma cell line ... Although, ASA itself had no effect on the NF-kappaB pathway, nor did it reduce DC-induced NF-kappaB translocation, it did prevent DC-induced caspase-3, -6 and -9 activation, poly ( ADP-ribose ) polymerase and lamin A processing, DNA degradation, and PKC signaling, all indices of apoptosis
Williams et al., Carcinogenesis 2008 (Adenocarcinoma) : We studied in several human colon ( HT-29, HCT-15, LoVo, HCT116 and SW-480 ), pancreatic ( BxPC-3, MIA PaCa-2 ) and breast ( MDA-MB-231 and MCF-7 ) cancer cell lines, the effect of NO-ASA on NF-kappaB activation, determined by electrophoretic mobility shift assays, immunofluorescence and western blot analyses of nuclear proteins ... The effect of NO-ASA on NF-kappaB binding to DNA was significantly correlated with its effect on cell growth ( P < 0.05 ) indicating that the growth inhibitory effect of NO-ASA may be mediated by its effect on NF-kappaB
Joo et al., Eur J Pharmacol 2009 (Colitis) : Our results suggest that the anti-inflammatory effect of the prodrug on experimental colitis is attributed to the inhibition of the IL-1beta mediated NFkappaB activation and the taurine effect is through TauCl potentiating the ability of 5-ASA to inhibit IL-1beta dependent NFkappaB activation
Mazzeo et al., Eur J Immunol 1998 : Analysis of the regulation of the p40 gene promoter revealed that ASA inhibited NF-kappaB activation and binding to the p40-kappaB site in the p40 promoter, leading to transcriptional repression of the p40 gene