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ASCL1 — HES6

Text-mined interactions from Literome

Somasundaram et al., Oncogene 2005 (Astrocytoma...) : ASCL1 upregulation in progressive astrocytoma is accompanied by inhibition of Notch signaling as seen by uninduced levels of HES1, a transcriptional target of Notch1, increased levels of HES6 , a dominant negative inhibitor of HES1 mediated repression of ASCL1 , and increased levels of Notch ligand Delta1, which is capable of inhibiting Notch signaling by forming intracellular Notch ligand autonomous complexes
Nelson et al., Dev Dyn 2009 : We also reveal a role for Ascl1 in the regulation of Hes6 , a proneurogenic factor that inhibits Notch signaling to promote neural rather than glial differentiation