Gene interactions and pathways from curated databases and text-mining

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ATP5O — NOTCH3

Text-mined interactions from Literome

Vaccari et al., Development 2010 : These data indicate that V-ATPase , probably via acidification of early endosomes, promotes not only the degradation of Notch in the lysosome but also the activation of Notch signaling in endosomes
Sethi et al., J Biol Chem 2010 : Pharmacological inhibition of the V-ATPase complex significantly reduced Notch signaling in mammalian cells
Lange et al., Stem Cells Dev 2011 : Moreover, inhibition of the v-ATPase reduced endogenous Notch signaling and prevented the proliferative effect of a transmembrane, ?-secretase dependent, active Notch without blocking the effects of its cytoplasmic intracellular domain ( NICD )