Wang et al., J Pharmacol Exp Ther 2003
(Neurotoxicity Syndromes) :
PCP induced proapoptotic changes in Bax and Bcl-X ( L ) were also prevented by M40403 treatment
Wang et al., Biochem Pharmacol 2005
:
That is, western analysis showed that antisense ODNs directed against either NR1 or NR2A prevented PCP induced increases in Bax in addition to preventing the upregulation of the respective receptor proteins
Eliseev et al., Oncogene 2008
(Bone Neoplasms...) :
Furthermore, bone morphogenetic protein induced or vector mediated expression of Runx2 resulted in upregulation of Bax expression, and subsequent increased sensitivity of Saos2 cells to apoptosis