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BCL2 — IL6
Text-mined interactions from Literome
Puthier et al., Br J Haematol 1999
(Multiple Myeloma) :
In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and
Bcl-xL were tightly
regulated by
interleukin (IL)-6
Ding et al., Sheng Li Xue Bao 2002
:
The purpose of the present study was to determine the
effects of recombinant human
interleukin-6 ( rhIL-6 ) on the
Bcl-2 and Bax expression and apoptosis after anoxia-reoxygenation in cultured rat hippocampal neurons
Song et al., Chin Med J (Engl) 2002
(Multiple Myeloma) :
Mcl-1, instead of
Bcl-2 and Bcl-kappa ( L ),
plays an important role in
IL-6 deprivation induced apoptosis in XG-7 human myeloma cells
Leu et al., Oncogene 2003
(Esophageal Neoplasms) :
While
Bcl-2 , Bcl-x ( L, ), and Bax were not affected, Mcl-1 was
induced by
IL-6 in human esophageal carcinoma cells
Pu et al., Prostate 2004
(Prostatic Neoplasms) :
Among Bcl-2 family proteins, only
Bcl-xL was evidently
increased by
IL-6 stimulation
Waxman et al., Am J Respir Cell Mol Biol 2009
(Acute Lung Injury...) :
Overexpression of
IL-6 markedly diminishes hyperoxic lung injury, hyperoxia induced cell death, and DNA fragmentation, and
enhances Bcl-2 expression ... Consistent with this hypothesis, we found that
IL-6 induced
Bcl-2 expression, both in vivo and in vitro, disrupted interactions between proapoptotic and antiapoptotic factors, and suppressed H ( 2 ) O ( 2 ) -induced loss of mitochondrial membrane potential in vitro ... Taken together, our results suggest that
IL-6 induces
Bcl-2 expression to perform cytoprotective functions in response to oxygen toxicity, and that this effect is mediated by alterations in the interactions between Bak and Mfns
Neiva et al., Neoplasia (New York, N.Y.) 2009
(Carcinoma, Squamous Cell) :
Here, we observed that
Bcl-2 signaling
induces expression of
IL-6 , CXCL8, and EGF, providing a mechanism for the upregulation of these cytokines in tumor associated endothelial cells
KamiĆski et al., Pharmacol Rep 2009
(Disease Models, Animal...) :
Effect of
interleukin 6 deficiency on the expression of
Bcl-2 and Bax in the murine heart
Kathiria et al., Cancer Res 2012
(Colitis...) :
In wild-type p53 cells, PHB overexpression decreased basal and
interleukin-6 induced STAT3 activation and expression of the STAT3 responsive genes
Bcl-xL and Bcl-2
Wakisaka et al., Clin Exp Immunol 1998
(Arthritis, Rheumatoid) :
Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro, and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta, but not
IL-6 or IL-8,
inhibited the anti-Fas induced apoptosis accompanying up-regulation of
Bcl-2 protein expression and reduced expression of CPP32 and ICH-1L. Immunohistochemical study revealed that CPP32 and ICH-1L were expressed weakly in the RA synovial lining cells compared with osteoarthritis ( OA ) synovial lining cells
Oritani et al., Blood 1999
:
During this process,
IL-6 downregulated expression of BCL2 in 1A9-M cells and
stimulated BCL-XL expression, but had no effect on p53, Bax, or Bak gene expression