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BCL2 — TNF

Text-mined interactions from Literome

Tamatani et al., J Biol Chem 1999 : Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons ... Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both TNF induced up-regulation of Bcl-2 and Bcl-x expression and neuroprotective effect
Rojas et al., J Immunol 1999 : Anti-TNF-alpha inhibited apoptosis, diminished NO- production, p53, and caspase 1 activation and increased Bcl-2 expression
Katschinski et al., Cancer Res 1999 (Fever...) : The threshold temperature for the onset of apoptosis was 42 degrees C. Whereas hyperthermia exerted no effect on the expression of Bcl-2 and Bax, heat induced a > 30-fold increase of tumor necrosis factor (TNF) alpha mRNA expression and a significant increase in TNF-alpha protein secretion
Breitschopf et al., Mol Cell Biol 2000 (MAP Kinase Signaling System) : Moreover, we show that oxidative stress mediates TNF-alpha stimulated proteolytic degradation of Bcl-2 by reducing MAP kinase activity
Marselli et al., J Clin Endocrinol Metab 2001 : IL-1beta, interferon gamma, and TNF alpha caused no major change in either islet cell survival or Bcl-2 and Bax mRNA expression after a 12-h incubation ; however, a marked increase in the amount of dead cells, with a major decrease of Bcl-2 mRNA expression, was observed after 72 h
Catz et al., Oncogene 2001 (Adenocarcinoma...) : Here we show that an increase in the level of expression of Bcl-2 in the human prostate carcinoma cell line LNCaP observed in response to hormone withdrawal is further augmented by TNF-alpha treatment, and this effect is abated by inhibitors of NF-kappa B
Soeda et al., Life Sci 2001 : Moreover, crocin suppressed the TNF-alpha induced expression of Bcl-Xs and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression
Kim et al., J Pharmacol Exp Ther 2002 : In conclusion, cilostazol and its analogs exert a strong protection against apoptotic cell death by scavenging hydroxyl radicals and intracellular ROS with reduction in TNF-alpha formation and by increasing Bcl-2 protein expression and decreasing Bax protein and cytochrome c release
Grünenfelder et al., J Heart Lung Transplant 2002 (Disease Models, Animal...) : Bcl-2 is down-regulated and TNF-alpha up-regulated in this model of ischemia-reperfusion injury
Rajah et al., Cell Growth Differ 2002 : The effect of TNF-alpha on Bcl-2 serine phosphorylation was blocked by IGFBP-3 antisense oligomers
Sasson et al., Biochem Biophys Res Commun 2002 : TNF alpha dramatically reduced intracellular levels of Bcl-2 , while Dex abrogated this reduction
Park et al., J Biochem Mol Biol 2002 (MAP Kinase Signaling System) : Accordingly, Bcl-2 , an anti-apoptotic Bcl-2 family member, was highly expressed in response to TNF-alpha
Maruo et al., Steroids 2003 (Leiomyoma...) : Treatment with P4 augmented EGF and Bcl-2 protein expression, but inhibited IGF-I and TNFalpha expression in cultured leiomyoma cells
Chandrasekar et al., J Biol Chem 2004 (Inflammation) : Treatment of HCMEC with IL-18 increases 1 ) NF-kappaB DNA binding activity ; 2 ) induces kappaB-driven luciferase activity ; 3 ) induces IL-1beta and TNF-alpha expression via NF-kappaB activation ; 4 ) inhibits antiapoptotic Bcl-2 and Bcl-X ( L ) ; 5 ) up-regulates proapoptotic Fas, Fas-L, and Bcl-X ( S ) expression ; 6 ) induces fas and Fas-L promoter activities via NF-kappaB activation ; 7 ) activates caspases-8, -3, -9, and BID ; 8 ) induces cytochrome c release into the cytoplasm ; 9 ) inhibits FLIP ; and 10 ) induces HCME cell death by apoptosis as seen by increased annexin V staining and increased levels of mono- and oligonucleosomal fragmented DNA
Chen et al., J Cardiovasc Pharmacol Ther 2004 : Pretreatment of cells with the PPAR-gamma ligand pioglitazone blocked TNF-alpha mediated apoptosis, caspase-3 activation, expression of Bcl-2 , and lipid peroxidation ( P < .01 vs TNF-alpha alone )
Ramana et al., FEBS Lett 2004 : Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha induced increase in Bax and Bak and the downregulation of Bcl-2
Engel et al., Am J Physiol Heart Circ Physiol 2004 (Ventricular Remodeling) : Additional studies suggested that the TNF induced decrease in Bcl-2 expression and activation of the intrinsic mitochondrial death pathway were responsible for the cardiac myocyte apoptosis observed in the MHCsTNF mice
Guillemard et al., Virology 2004 : Furthermore, using an inhibitor of NF-kappaB activation, we demonstrated that TNF induced upregulation of Bcl-x ( L ) and Bcl-2 occurs, respectively, through a NF-kappaB dependent and an NF-kappaB independent pathway
Suominen et al., Eur J Endocrinol 2004 : The prosurvival effect of TNF-alpha might be at least partly mediated by modulating the expression and subcellular localization of Bcl-2 family proteins
Yang et al., Zhonghua Gan Zang Bing Za Zhi 2005 : [ Bcl-xl blocks tumor necrosis factor alpha induced caspase 8 activation and apoptosis ]
Zhang et al., Arthritis Rheum 2005 (Arthritis, Experimental...) : Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis, and TNF stimulated Bcl-xL and Ets-2 expression in osteoclasts
Wang et al., Clin Cancer Res 2005 (Breast Neoplasms...) : Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted TNF-alpha induced stability of p53, up-regulation of phospho-p53ser15, p21waf/cip, and Bax, and down-regulation of Bcl-2 and Bcl-xL , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing
Cheng et al., Life Sci 2006 : The TNF alpha induced ROS generation, lipid peroxidation, antioxidant enzyme consumption, a proapoptotic predominant expression of Bcl-2 family proteins, and a disruption of mitochondrial membrane potential were all inhibited by E2, and then they were further stimulated by progesterone in HuH-7 cells
Leroy et al., Biol Reprod 2007 (Inflammation) : Exogenous TNF mimicked LPS treated choriodecidua conditioned medium in that it induced myometrial cell apoptosis, reduced BCL2 expression, and increased BAX expression
Yang et al., Am J Physiol Heart Circ Physiol 2007 (MAP Kinase Signaling System) : CYP epoxygenase overexpression also significantly inhibited caspase-3 activity and downregulation of Bcl-2 expression induced by TNF-alpha
Dhingra et al., Am J Physiol Heart Circ Physiol 2007 : The antioxidant Trolox modulated TNF-alpha induced changes in Bax/Bcl-xl , cell injury, and MAPKs
Ahn et al., Cancer Res 2007 (Skin Neoplasms) : The induction of various antiapoptotic gene products ( MMP-9, cyclin D1, COX-2, IAP1, IAP2, Bcl-2 , cFLIP, and XIAP ) by TNF was also abolished in NQO2-/- cells
Campbell et al., J Urol 2008 (Ureteral Obstruction) : Renal obstruction induced increased tumor necrosis factor-alpha production, apoptotic renal tubular death, the expression of Bax, caspase 8 and truncated BID, and mitochondrial release of cytochrome C, while simultaneously stimulating decreased Bcl-2 and Bcl-x ( L ) expression
Park et al., Biochem Pharmacol 2011 (Inflammation...) : Triptolide also abrogated TNF induced expression of cell survival proteins ( XIAP, Bcl-x ( L ), Bcl-2 , survivin, cIAP-1 and cIAP-2 ), cell proliferative proteins ( cyclin D1, c-myc and cyclooxygenase-2 ), and metastasis proteins ( ICAM-1 and MMP-9 )
Wang et al., J Chemother 2012 (Breast Neoplasms) : Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells, suggesting that Bcl-2 is directly regulated by nuclear factor-kappaB (NF-kappaB) in response to TNF-alpha ... Silencing of sClu in MDA-MB-231/sClu siRNA cells abrogated TNF-alpha mediated NF-kappaB activation and Bcl-2 overexpression, and rendered the MDA-MB-231/sClu siRNA cells significantly more sensitive to TNF-alpha mediated apoptosis than the parental cells ... Furthermore, overexpression of sClu in MCF-7/sClu cells promoted TNF-alpha mediated NF-kappaB activity and Bcl-2 overexpression, and rendered the MCF-7/Clu cells significantly more resistant to TNF-alpha mediated apoptosis
Wang et al., World journal of surgical oncology 2013 (Carcinoma, Non-Small-Cell Lung...) : In the study, we designed to investigate the effect of TNF-a on the activation and expression of nuclear factor kappa B ( NF-?B ) /p65/SLUG/PUMA/Bcl-2 levels in human lung cancer A549 cell line, and in conditions of TNF-a induced apoptosis
Jäättelä et al., Oncogene 1995 (Breast Neoplasms) : Bcl-x and Bcl-2 inhibit TNF and Fas induced apoptosis and activation of phospholipase A2 in breast carcinoma cells
Genestier et al., Int Immunol 1995 : The increase of Bcl-2 expression induced by TNF-alpha was inhibited by chelerythrine, a specific inhibitor of protein kinase C ( PKC ), suggesting that Bcl-2 expression was dependent on PKC activation
Slowik et al., Lab Invest 1997 : TNF + CHX killing is effectively blocked by transfected CrmA protein or treatment with Z-VAD.fmk peptide-both inhibitors of interleukin-1 converting enzyme-like proteases-but not by transfected antiapoptotic proteins Bcl-2, Bcl-XL , or A1 ... TNF + cer killing, which can affect more than 50 % of EC, is not effectively inhibited by CrmA or Z-VAD frank, but can be readily blocked by Bcl-2, Bcl-XL , or A1
DeLuca et al., Virology 1998 : As was observed for the U9-IIIB cells, TNFalpha treatment also induced a marked decrease in Bcl-2 protein levels in TD-IkappaB expressing cells
Wright et al., Cancer Res 1998 : It was demonstrated that overexpression of Bcl-2 in either HL-60 or PW leukemia cell lines suppressed activation of AP24 induced by either tumor necrosis factor or UV light and protected cells from apoptosis