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BIK — CA2
Text-mined interactions from Literome
Mathai et al., J Biol Chem 2005
:
BH3-only
BIK regulates BAX, BAK dependent release of
Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress induced cell death ...
BIK initiates an early release of
Ca2+ from ER upstream of the activation of effector caspases ... Employing small interfering RNA knockdowns, we also demonstrated that release of ER
Ca2+ and mitochondrial apoptosis in human epithelial cells
requires BIK and that a Ca2+ regulated target, the dynamin related GTPase DRP1, is involved in p53 induced mitochondrial fission and release of cytochrome c to the cytosol
Priceman et al., Biochem Biophys Res Commun 2006
(Leukemia, Lymphoid) :
This report demonstrates that GC-mediated upregulation of the bZIP transcriptional repressor gene,
E4BP4 , is
dependent on [
Ca2+ ] i levels, and correlates with GC-evoked apoptosis of GC-sensitive CEM-C7-14 cells