Gene interactions and pathways from curated databases and text-mining

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BIK — CA2

Text-mined interactions from Literome

Mathai et al., J Biol Chem 2005 : BH3-only BIK regulates BAX, BAK dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress induced cell death ... BIK initiates an early release of Ca2+ from ER upstream of the activation of effector caspases ... Employing small interfering RNA knockdowns, we also demonstrated that release of ER Ca2+ and mitochondrial apoptosis in human epithelial cells requires BIK and that a Ca2+ regulated target, the dynamin related GTPase DRP1, is involved in p53 induced mitochondrial fission and release of cytochrome c to the cytosol
Priceman et al., Biochem Biophys Res Commun 2006 (Leukemia, Lymphoid) : This report demonstrates that GC-mediated upregulation of the bZIP transcriptional repressor gene, E4BP4 , is dependent on [ Ca2+ ] i levels, and correlates with GC-evoked apoptosis of GC-sensitive CEM-C7-14 cells