Gene interactions and pathways from curated databases and text-mining

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BMP4 — NOTCH2

Text-mined interactions from Literome

Glavic et al., Development 2004 : Activation of Xiro1 and of Notch signaling upregulated Hairy2A and inhibited Bmp4 transcription during neural crest specification
Nobta et al., J Biol Chem 2005 : Furthermore, our data also suggest that functional Notch signaling is essential not only for BMP2 induced osteoblast differentiation but also for BMP signaling itself
Chen et al., Nat Biotechnol 2008 : Microarray analyses reveal that this respecification is mediated in part through the coordinated regulation of the BMP and Wnt pathways by Notch signaling
Morikawa et al., Nucleic Acids Res 2011 : Furthermore, we characterized EC-specific Smad1/5 target genes and found that several Notch signaling pathway related genes were induced by BMP in ECs
Larman et al., Cell Signal 2012 : Interestingly, our gene profiling analysis shows that BMP signaling activates a number of Notch regulated transcription factors, including HEY1
Laurent et al., Dev Neurobiol 2012 : In retinal neurons and Müller cell cultures, CCN3 expression is induced by activated BMP signaling, whereas Notch signaling decreases CCN3 mRNA and protein levels in Müller cells and has no effect in retinal neurons
Zhou et al., Proc Natl Acad Sci U S A 2013 : Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye