Gene interactions and pathways from curated databases and text-mining

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CAPN14 — RELA

Text-mined interactions from Literome

Kim et al., Parasitol Res 2001 (Toxoplasmosis) : An inhibitor of NF-kappaB activation, calpain-1 inhibitor , blocked the chemokine secretion induced by live T. gondii
Schölzke et al., Eur J Neurosci 2003 : Our data indicate that the Ca2+ dependent protease calpain is involved in the NF-kappaB activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate ... NF-kappaB activation by calpain may mediate the long-term effects of glutamate on neuron survival or memory formation
Clark et al., Exp Cell Res 2004 (Leukemia, Promyelocytic, Acute) : This maturation response involves protein kinase C ( PKC ) signaling, activation of the transcription factor nuclear factor kappaB (NFkB) , and intracellular calcium and calpain activity
Yang et al., Chem Res Toxicol 2007 (Necrosis) : It reduces mitochondrial membrane potential by activating calpain and inhibits NF-kappaB activity by increasing the ROS level
Wei et al., Am J Physiol Cell Physiol 2009 : Altogether, the data demonstrate a signaling pathway by which titanium particles induce oxidative stress, stimulate calpain mediated NF-kappaB activation, and activate target gene expression, including COX-2
Chen et al., Arch Biochem Biophys 1997 : This suggests that calpain contributes to silica induced I kappa B alpha degradation and NF-kappa B activation but not to LPS induced I kappa B alpha degradation and NF-kappa B activation