Cheng et al., Am J Physiol Heart Circ Physiol 2009
:
These results indicate that shear induced platelet-VWF interaction results in calpain and metalloproteinase dependent GPIbalpha ectodomain shedding
Nomura et al., Rinsho Byori 1997
(Arteriosclerosis...) :
Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of von Willebrand factor to platelet glycoprotein Ib, influx of extracellular calcium, and activation of platelet calpain were required to generate microparticles under high shear stress conditions