Gene interactions and pathways from curated databases and text-mining

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CASP3 — IKBKG

Text-mined interactions from Literome

Chen et al., Crit Care Med 2007 (Burns...) : IKK blocks caspase 3 expression by up-regulating BCL-xL and cellular FLICE inhibitory protein expression
Frelin et al., Cell Death Differ 2008 : Inhibition of the NF-kappaB survival pathway via caspase dependent cleavage of the IKK complex scaffold protein and NF-kappaB essential modulator NEMO
Oh et al., J Pharmacol Exp Ther 2011 (Inflammation...) : In activated human mast cells, the receptor interacting protein 2 (RIP2), I?B kinase ( IKK ) -ß, nuclear factor-?B ( NF-?B ) /RelA, and caspase-1 activation were increased, but increased RIP2, IKK-ß , NF-?B/RelA, and caspase-1 activation were inhibited by the treatment of IPT