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CASP6 — EPHB2

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Han et al., J Neurosci 2000 (Hypoxia-Ischemia, Brain) : Pharmacological inhibition of ERK , but not the PI3-kinase pathway, inhibited the ability of BDNF to block H-I induced caspase-3 activation and tissue loss
Tashker et al., Mol Biol Cell 2002 : Concomitantly, we have also demonstrated that recombinant Mos, MEK, and ERK are sufficient to block cytochrome c-dependent caspase activation in purified Xenopus cytosol, which lacks both transcription and translation
Varghese et al., J Biol Chem 2002 : Head involution defective ( Hid ) -triggered apoptosis requires caspase-8 but not FADD ( Fas associated death domain ) and is regulated by Erk in mammalian cells
Rabelo et al., Biochem Biophys Res Commun 2003 (Fibrosarcoma) : The butyrate effect was shown to be dependent on caspase activation, once caspase inhibitors restored phosphorylation of ERK1/2 and CREB in 2C4 cells
Adayev et al., Biochim Biophys Acta 2003 : However, both GFX and the PKCalpha and PKCbeta ( 1 ) inhibitor Gö6976 reversed the ERK1/2 mediated inhibition of caspase-3
Zhang et al., J Biol Chem 2003 : Despite this, it completely suppresses PICD by sustaining ERK activation and inhibiting caspase 8 activation in phagocytosing neutrophils
Milani et al., J Neurochem 2003 (Neuroblastoma) : Remarkably, caspase dependent cleavage of NF-kappaB family members as well as of Akt and CREB proteins, but not of ERK , became prominent at 24 h, a time point coincident with the peak of caspase dependent apoptosis
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta ) ... Specific inhibition of ERK1/2 diminished Fas ligation induced caspase-1 activation, IL-1beta secretion, and ensuing up-regulation of developmental markers, whereas treatment with neutralizing anti-IL-1beta antibody abrogated phenotypic and functional maturation, indicating that IL-1beta mediates Fas ligation induced DC maturation in an autocrine manner
Park et al., J Biol Chem 2003 : Activation of ERK1/2 by pretreatment with phorbol 12-myristate 13-acetate or forced expression of ERK1/2 attenuated phytosphingosine induced caspase-8 activation
Lee et al., J Neurochem 2004 : Interestingly, inhibition of ERK dramatically increased mitochondrial malfunction, and enhanced caspase activation, resulting in enhanced neuronal cell death
Zhang et al., Exp Cell Res 2004 : Preincubation with hsp60 strongly induced phosphorylation of ERK1/2 and inhibited UV radiation mediated activation of caspase 3
Liu et al., J Bone Miner Res 2004 : The anti-apoptotic effect of calbindin-D28k involves inhibition of glucocorticoid induced caspase 3 activation as well as ERK activation
Marchetti et al., Cell Death Differ 2004 : p53 can inhibit cell proliferation through caspase mediated cleavage of ERK2/MAPK ... Furthermore, caspase inhibitors or expression of a caspase-resistant ERK2 mutant interfere with ERK2 cleavage and restore proliferation in the presence of p53 activation, indicating that caspase mediated ERK2 degradation contributes to p53 induced growth arrest
Yacoub et al., Cancer Biol Ther 2004 (Brain Neoplasms...) : Inhibition of caspase 9 after combination treatment blunted neither JNK1/2/3 activation nor the enhanced expression of BAD and BAX, but did block caspase 3 cleavage, reduced expression of BCL-XL and inhibition of ERK1/2 activity
Schweyer et al., Br J Cancer 2004 (MAP Kinase Signaling System...) : Functional assays using MEK inhibitors demonstrated that the phosphorylation of MEK and ERK was required for the activation of caspase-3 as the executing caspase
Kaushal et al., American journal of physiology. Renal physiology 2004 : Inhibition of ERK1/2 phosphorylation but not P38 and JNK kinase increased caspase-3 and -9 activation ; however, this activation was far less than induced by inhibition of Akt phosphorylation ... Thus the Akt mediated phosphorylation pathway, ERK signaling, and the antiapoptotic Bcl-2 proteins distinctly regulate caspase activation during oxidant injury to RTE
Schweyer et al., Int J Oncol 2004 (Neoplasms, Germ Cell and Embryonal...) : Functional assays using chemical inhibitors demonstrated that the phosphorylation of ERK was mediated by reactive oxygen species in an Raf-1 independent manner and required the activation of caspase-3
Tuo et al., Life Sci 2004 (MAP Kinase Signaling System) : The opposing effects of onychin on phosphorylation levels of p38MAPK and ERK1/2 , and its caspase-3 inhibition might play a role in the beneficial effect of onychin on endothelial injury
Ríos-Muñoz et al., J Neurochem 2005 (MAP Kinase Signaling System...) : In the present study we used western blotting and immunocytochemistry to investigate the effects of this FGF-2 treatment upon the activation of the extracellular signal regulated kinase ( ERK ) pathway, the amounts and distribution of Bcl-2 family proteins, and the activation of caspase-3
Shih et al., Food Chem Toxicol 2005 (Adenocarcinoma...) : In addition, the malvidin treatment significantly increased the p38 kinase expression and inhibited the ERK activity, and the effects of malvidin on caspase-3 activation were blocked , respectively, by the ERK and p38 inhibitors
Lüschen et al., Exp Cell Res 2005 : This conclusion is based on the following observations : ( I ) Overexpression of FADD, caspase-8 , or a c-FLIP protein containing the death effector domains only leads to enhanced and prolonged ERK activation after TNF treatment ... Interestingly, the enzymatic function of caspase-8 is not required for TNF induced ERK activation
Weiderhold et al., Int J Cancer 2006 (Mammary Neoplasms, Animal) : Bcl-2 phosphorylation and activation of ERK and JNK and caspase 3-dependent cleavage of PARP were observed in MDA-MB-435 cells treated with CB694
El Btaouri et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : The permeable exogenous C ( 2 ) -ceramide reproduces IL-1beta effects on: (i) inhibition of adenylyl cyclase activity, ( ii ) down-regulation of ERK1/2 phosphorylation, ( iii ) activation of caspase-3 , and ( iv ) apoptosis in pig thyroid cells
Panner et al., Cell cycle (Georgetown, Tex.) 2006 : While TRAIL sensitivity in tumors has been linked to c-myc- and MEK/Erk induced enhancement of caspase activation, our recent study identified a third input controlling TRAIL sensitivity, namely the Akt-mTOR pathway
Kim et al., Environ Toxicol Chem 2005 (Necrosis) : Inhibition of ERK phosphorylation by PD98059 strongly attenuated cadmium induced necrotic cell death, but did not prevent caspase-3 activation and DNA fragmentation
Cagnol et al., Apoptosis 2006 : Prolonged activation of ERK1,2 induces FADD independent caspase 8 activation and cell death ... Accordingly, prolonged ERK stimulation activated caspase 8 and strongly potentiated Fas signaling ... These findings reveal that prolonged ERK/MAPK stimulation results in caspase 8 activation and cell death
Sumizawa et al., Arch Toxicol 2007 : Thus, although mechanisms other than caspase dependent apoptosis may be involved, apoptotic process seems to take place in the genesis of toxicity of acrylamide in SH-SY5Y cells through ERK pathway and activation of caspase-3
Raymond et al., Endocrinology 2006 (Leiomyoma...) : A pharmacological approach showed that the effect of ET-1 on caspase-3/7 activation in ELT3 cells was not dependent on phosphatidylinositol 3-kinase, ERK1/2 , or phospholipase D activities
Xu et al., Atherosclerosis 2007 : Inhibitors of the Akt, ERK1/2 , Src kinase and transfection with a dominant negative Akt cDNA blocked the inhibitory effect of cyanidin on cleaved caspase-3
Huang et al., Am J Physiol Cell Physiol 2007 : Moreover, inhibition of ERK phosphorylation potentiated serum withdrawal induced caspase-3 activity
Ou et al., Eur J Pharmacol 2007 (Carcinoma, Renal Cell...) : Selective inhibitors of ERK , p38 MAPK, and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin induced cytotoxicity and reduced increased caspase activity
Zhou et al., Cell Prolif 2007 (MAP Kinase Signaling System) : The suppression of MEK1/ERK1/2 activation inhibited UV-induced expression of c-Fos and JunD and increased caspase 3 activity and cell death
Bhoopathi et al., J Biol Chem 2008 (MAP Kinase Signaling System...) : ERK inhibition, using a kinase-dead mutant for ERK, ameliorated NF-kappaB activation and caspase mediated apoptosis in Ad-MMP-9 infected cells
Aprigliano et al., Liver Int 2008 (Disease Models, Animal) : Atorvastatin induces apoptosis in activated HSCs acting through an ERK dependent cleavage of Bid and a highly increased protease activity of caspase-9 and -3
Zhou et al., Toxicol Appl Pharmacol 2008 : Knockdown of JWA attenuated arsenic trioxide induced apoptosis, and was accompanied by significantly reduced activity of caspase-9 , enhanced Bad phosphorylation and inhibited MEK1/2, ERK1/2 and JNK phosphorylations
Kong et al., Purinergic Signal 2005 : BzATP also induced the activation of C-jun N-terminal kinase 1 ( JNK1 ) and extracellular signal regulated kinases ( ERK1/2 ) in rPCNs, and pharmacological inhibition of either JNK1 or ERK1/2 significantly reduced caspase activation by BzATP
Monick et al., J Immunol 2008 : ERK inhibition led to cytosolic release of mitochondrial proteins and caspase activation
Zhang et al., Toxicology 2008 : Inhibition of ERK1/2 activation sensitized hepatocytes to death and increased activity of caspase-9 and 3 in response to toosendanin
Cheng et al., Int J Cancer 2008 (Lung Neoplasms...) : Moreover, caspase-3 induced ERK activation ... In summary, caspase-3 induces ERK activation through a ceramide-dependant, protease activity independent mechanism, which represents a novel role of caspase-3 in tumor metastasis
Kim et al., Biol Pharm Bull 2009 (Hearing Disorders) : HGCYT inhibited the cell death, reactive oxygen species generation ( ROS ), activation of caspase-9 , and extracellular signal related kinase ( ERK ) induced by Cd ( 2+ )
Hasegawa et al., J Immunol 2009 : ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK
Yang et al., BMC biology 2009 (Brain Ischemia...) : Since ERK and cytochrome c are differentially involved in caspase signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion, we considered if DOR activation protects the ischemic brain by attenuating oxidative injury
Gatson et al., Journal of neuroinflammation 2009 (Burns...) : In addition, we determined that in the estrogen treated rats there was an increase in the levels of phospho-ERK ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol blocked the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 )
Kim et al., J Toxicol Environ Health 2009 : Fifty micromolar HQ markedly increased phosphorylation of ERK and activation of caspase-9/-3 , followed by PARP cleavage
Lennartsson et al., Cell Signal 2010 : However, reduction of the expression of Erk5 by siRNA resulted in only a transient Akt phosphorylation, and an inability of PDGF-BB to suppress caspase 3 activation and inhibit apoptotic nuclear morphological changes such as condensed or fragmented chromatin under serum-free conditions
Inamura et al., J Anesth 2010 (Reperfusion Injury) : This caspase activation is mediated by phosphorylation of Akt and ERK
Härtel et al., Am J Physiol Cell Physiol 2010 : This endogenous process involves MEK/ERK mediated inhibition of the pro-apoptotic molecule Bad and caspase 3
Zeng et al., J Ethnopharmacol 2010 : In addition, MWG extract attenuated activation of caspase-3 and poly ADP-ribose polymerase ( PARP ) and inhibited the phosphorylation of ERK , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs
Snyder et al., AIDS 2010 (AIDS-Associated Nephropathy...) : Since sustained ERK activation can activate caspase-8 in some cell types, we studied the role of ERK in Vpr induced caspase-8 activation
Lee et al., Endocrinology 2010 (Spinal Cord Injuries) : Ghrelin significantly inhibited apoptotic cell death of neurons and oligodendrocytes, release of mitochondrial cytochrome c, and activation of caspase-3 after moderate contusion SCI. Ghrelin also significantly increased the level of phosphorylated ERK but decreased the level of phosphorylated p38MAPK
Scherbik et al., J Virol 2010 (MAP Kinase Signaling System...) : Reduction of Ca ( 2+ ) influx at early times of infection by various treatments decreased the viral yield and delayed both the early transient caspase 3 cleavage and the activation of FAK, Akt, and ERK signaling
Lu et al., Sci China Life Sci 2010 : Full inhibition of caspase-3 activity reduced Mst1 activation and partially inhibited H2B phosphorylation ( Ser14 ), but ERK1/2 , JNK1/2 and p38 activities were not affected
Lee et al., Mol Biol Cell 2010 : HGF also blocked Ang II-induced caspase-3 activation and lactate dehydrogenase release in tissue explants in an ERK dependent manner
Yang et al., Biochem Pharmacol 2011 (Liver Neoplasms) : In fenretinide sensitive Huh7 cells, activation of ERK1/2 by epidermal growth factor (EGF) prevented fenretinide induced cell death and caspase 3/7 induction
Tsuda et al., BMC neuroscience 2011 (Sciatic Neuropathy) : In the present study, axonal outgrowth, activation of ERK1/2 by phosphorylation ( p-ERK 1/2 ) and immunoreactivity of cleaved caspase 3 were examined after immediate, delayed, or no repair of transected rat sciatic nerves
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation, while did not affect the degradation of I?Ba, activation of ERK or p38, and processing of caspase-3 induced by TNF-a
Jabbour et al., Transplantation 2011 (Myocardial Reperfusion Injury) : Functional improvements were accompanied by increased phosphorylation of Akt, ERK1/2 , STAT3, and GSK-3ß and reduced cleaved caspase-3 ( P < 0.01 )
Tomiyama et al., Cell death & disease 2010 (Glioma) : MEK-ERK dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death
Xiang et al., Cell Biochem Funct 2011 : The inhibitory effect of ghrelin on caspase-3 activity was attenuated by inhibitors of ERK1/2 ( PD98059 ), PI3K/Akt ( LY294002 ) and growth hormone secretagogue receptor ( GHSR ) -1a ( D-Lys ( 3 ) -growth hormone releasing peptide-6 )
Jantas et al., Neurotoxicology 2011 : The obtained data provided evidence for neuroprotective potency of MAPK/ERK1/2 and calpain, but not caspase-3 inhibition against the neurotoxic effects of LC in primary cortical neurons and give rationale for using these inhibitors in the treatment of neurodegenerative diseases connected with proteasome dysfunction
Brama et al., J Endocrinol Invest 2012 (MAP Kinase Signaling System...) : In conclusion, at least 2 pathways appear activated by cadmium in osteoblasts : a direct induction of caspase-8 followed by activation of caspase-3 and an indirect induction by phosphorylation of ERK1/2 , p38, and JNK MAPK triggering activation of caspase-8 and -3
Liu et al., Int J Biochem Cell Biol 2011 (Breast Neoplasms) : Taken together, our data indicate that Akt/ERK mediated caspase-8 activation and Fas/FasL mediated caspase-8 activation mostly elucidate doxorubicin induced death in MCF-7 cells and MCF-7/Dox cells, respectively
Karmarkar et al., PloS one 2011 (MAP Kinase Signaling System) : Facilitation of ERK activation and inhibition of caspase activation promotes resistance to Glu excitotoxicity in SCN2.2 cells
Beharier et al., J Mol Med (Berl) 2012 (MAP Kinase Signaling System...) : Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased caspase activation following I/R. Phospho-ERK levels were significantly increased following I/R in cells overexpressing ZnT-1, while knockdown of ZnT-1 reduced phospho-ERK levels
Bodai et al., Bioessays 2012 (Huntington Disease...) : In response to mutant Htt, ERK is activated and directs a protective transcriptional response and inhibits caspase activation
Zhai et al., Pharmacol Rep 2011 : Moreover, CSTMP showed stronger effects on the inhibition of apoptosis, caspase-3 expression, and the activation of phosphorylated ERK1/2 compared to RES
Yuan et al., Biochem Biophys Res Commun 2012 (MAP Kinase Signaling System) : The activation of ERK increased XIAP expression and led to decreased caspase activation
Han et al., Cell Signal 2012 : In addition, down-regulation of ERK resulted in activation of caspase 3 and caspase 9
Park et al., Int J Oncol 2013 : ROS and ERK1/2 mediated caspase-9 activation increases XAF1 expression in dexamethasone induced apoptosis of EBV transformed B cells ... These results demonstrated that Dex mediated activation of caspase-9 via ROS generation and ERK1/2 pathway activation resulted in the activation of caspase-8 and the increment of XAF1, thereby induced apoptosis of EBV transformed B cells