Gene interactions and pathways from curated databases and text-mining

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CCK — IL1B

Text-mined interactions from Literome

Ling et al., World J Gastroenterol 2001 (Shock, Septic) : CCK-8 significantly inhibited the LPS induced increase in serum TNF-alpha IL-1beta and IL-6 ... In the heart, CCK-8 significantly inhibited LPS induced increase of TNF-alpha ( 864 +/- 123 ng.L ( -1 ) in CCK-8+LPS group vs 1599 +/- 227 ng.L ( -1 ) in LPS group, P < 0.01 ), and IL-1beta ( 282 +/- 93 ng.L ( -1 ) in CCK-8+LPS group vs 621 +/- 145ng.L ( -1 ) in LPS group, P < 0.01 )
Meng et al., Sheng Li Xue Bao 2002 (Shock, Septic) : The results showed that CCK-8 alleviated LPS induced decrease in MAP of rats ; compared with the control, LPS elevated the levels of TNF-alpha, IL-1 beta and IL-6 in serum and lung significantly, while CCK-8 significantly inhibited the LPS induced increases in TNF-alpha, IL-1 beta and IL-6 in serum and lung
Li et al., Shock 2007 : CCK-8 inhibits LPS induced IL-1beta production in pulmonary interstitial macrophages by modulating PKA, p38, and NF-kappaB pathway ... In this study, we have examined the possible signaling pathways by which CCK-8 inhibits lipopolysaccharide (LPS) induced IL-1beta production in rat pulmonary interstitial macrophages