Gene interactions and pathways from curated databases and text-mining

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CCL20 — TNF

Pathways - manually collected, often from reviews:

  • WikiPathways EBV LMP1 signaling: NFKB1/RELA → Complex of CXCL8-IFNB1-CCL20-TNF-CCL5 (activation)

Text-mined interactions from Literome

Matsui et al., Clin Exp Immunol 2001 (Arthritis, Rheumatoid) : Cultured synovial fibroblasts derived from either RA or OA patients were capable of producing MIP-3 alpha in response to IL-1 beta and TNFalpha in vitro
Tohyama et al., J Dermatol Sci 2001 : Based on these results, we postulate that MIP-3alpha produced by keratinocytes in the spinous layer in response to TNF-alpha stimulation is a key chemokine responsible for the epidermal recruitment of Langerhans cells
Sugita et al., J Immunol 2002 : Induction of macrophage-inflammatory protein-3alpha gene expression by TNF dependent NF-kappaB activation ... MIP-3alpha transcription was stimulated by TNF , and this stimulation was inhibited by an NF-kappaB inhibitor, I-kappaBalpha superrepressor
Abiko et al., Arch Oral Biol 2003 (Carcinoma, Squamous Cell...) : The expression of MIP-3alpha was upregulated by infection with Actinobacillus actinomycetemcomitans and by stimulation with lipopolysaccharide and TNF-alpha
Ruth et al., Lab Invest 2003 (Arthritis, Rheumatoid...) : IL-1beta, IL-18, and TNF-alpha stimulated RA fibroblast MIP-3alpha production at 48 hours of incubation in vitro
Starner et al., Am J Respir Cell Mol Biol 2003 : Expression of CCL20 transcripts were significantly induced by interleukin (IL)-1beta and tumor necrosis factor-alpha , and inhibited by dexamethasone
Veckman et al., J Leukoc Biol 2003 : CCL19 and CCL20 mRNA expression was up-regulated by IL-1beta or tumor necrosis factor alpha (TNF-alpha) , and in addition, IFN-alpha together with TNF-alpha further enhanced CCL19 gene expression
Kaser et al., J Clin Immunol 2004 (Colitis, Ulcerative...) : TNF-alpha increased and anti-TNF-alpha decreased CCL20 release in healthy control CEC but not in involved IBD colonic specimens
Kawano et al., Fertil Steril 2004 (Infertility, Female) : The effects of interleukin (IL)-1alpha, IL-1 receptor antagonist (RA), and tumor necrosis factor (TNF)-alpha on the secretion of MIP-3alpha by primary cultured granulosa-lutein cells and an immortalized granulosa cell line ( GC1a ) were investigated ... Our data suggest that MIP-3alpha was present in follicular fluid and correlated with oocyte maturation, and was regulated by IL-1alpha and TNF-alpha
Crane-Godreau et al., Infect Immun 2005 : In response to LPS, LTA, and Pam ( 3 ) Cys ( EMC Microcollection GmbH, Tubingen, Germany ), CCL20 levels increased ( 4- to 10-fold ) while PAMPs caused increased TNF-alpha ( 1- to 4-fold ) in the medium collected after 24 h of incubation
Lee et al., Exp Mol Med 2005 : A pharmacologic study also revealed that multiple signaling pathways are differentially involved in CCL20 production by DFO, while some of those pathways are not involved in TNF-alpha induced CCL20 production
Hosokawa et al., Clin Exp Immunol 2005 : Here, we report that interleukin-1 beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and Escherichia coli lipopolysaccharide (LPS) can significantly induce the production of CCL20 by HGF ... We found that TNF-alpha and E. coli LPS enhanced the production of CCL20 by HGF treated with IL-1beta ... Moreover, we demonstrated that nuclear factor-kappaB (NF-kappaB), p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinases ( ERK ) play an important role in mediating the production of CCL20 induced by IL-1beta and TNF-alpha
Hasan et al., J Immunol 2006 (Melanoma) : CCL20 production was up-regulated by IL-1alpha and TNF-alpha in all cell lines tested, and in human metastatic melanoma cells
Choi et al., World J Gastroenterol 2006 : DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells ... Treatment of AGS cells with DA-9601 reduced TNF-alpha induced IL-8 and CCL20 promoter activities, as well as their gene expression and protein release
Marcet et al., J Cell Physiol 2007 : Furthermore, UTP had no effect on interleukin-(IL)-8 release and reduced the release of both CCL20 and IL-8 induced by TNF-alpha and LPS
Kageyama et al., Rheumatol Int 2007 (Arthritis, Gouty...) : TNF-alpha induced MIP-3alpha but not IL-23 production in cultured synovial cells from RA patients
Takahashi et al., Oral Microbiol Immunol 2008 (Pulpitis) : Moreover, CCL20 production from pulpal fibroblasts was increased by stimulation with inetrleukin-1beta and tumor necrosis factor-alpha
Tanida et al., Cytokine 2009 (Arthritis, Rheumatoid) : IL-1beta vigorously induced the production of CCL20 from FLSs of human RA and the production of CCL20 induced by TNF-alpha was partially attributed to a trace amount of IL-1beta induced by TNF-alpha ... The production of CCL20 induced by TNF-alpha and IL-1beta was modified by helper-T-cell derived cytokines
Wang et al., Arch Oral Biol 2009 (Autoimmune Diseases...) : Collectively, TNF-alpha dependent activation of the extrinsic apoptotic pathway leads to upregulation of ICAM-1 and CCL20 in HSG in vitro
Shibata et al., J Invest Dermatol 2010 (Psoriasis) : Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha induced production of IL-1alpha and CCL20
Wang et al., Virology journal 2010 (Condylomata Acuminata) : CCL-20 expression can be increased by TNF-a and IL-1a
Kanda et al., Endocrinology 2011 (Psoriasis) : Visfatin enhanced TNF-a induced CXC chemokine ligand ( CXCL ) 8, CXCL10, and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Kim et al., Exp Dermatol 2011 (Psoriasis) : We demonstrated that IL-1ß, TNF-a , and IL-17A significantly increased CCL20 production from HaCaT cells
Iwamoto et al., Clin Immunol 2013 (Hepatitis, Autoimmune) : Administering anti-TNF-a did not prevent splenic T-cell activation, but did suppress hepatic CCL20 expression ... TNF-a stimulation enhanced CCL20 expression in hepatocytes
Kok et al., Arthritis Rheum 2013 (Arthritis, Experimental...) : In RASFs, simvastatin suppressed the tumor necrosis factor a (TNFa) induced production of CYR-61 and CCL20
Kitagawa et al., Surgery 2013 (Disease Models, Animal...) : Inhibition of CCL20 increased serum tumor necrosis factor (TNF)-a ( 3.3-fold greater than control mice ) and decreased serum interleukin (IL)-1a and IL-6
Son et al., Journal of inflammation (London, England) 2013 : Finally, CCL20 and CXCL8 responded synergistically in response to EGF and TNF in OVCAR-3 and SKOV-3 cells