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AKT3 — CD28

Text-mined interactions from Literome

Jones et al., J Exp Med 2002 : CD28 dependent activation of protein kinase B/Akt blocks Fas mediated apoptosis by preventing death inducing signaling complex assembly
Li et al., J Immunol 2005 : We also analyze Akt and glycogen synthase kinase-3beta phosphorylation in response to stimulation of CD28 alone
Li et al., Blood 2005 : T-cell receptor (TCR)-CD3/CD28 mediated activation of Rap1 and Akt was retained in Tregs, but activation of Ras, mitogenactivated protein kinase 1/2 ( MEK1/2 ), and extracellular signal regulated kinase 1/2 ( Erk1/2 ) was impaired
Parry et al., Mol Cell Biol 2005 : Ligation of both CTLA-4 and PD-1 blocked CD3/CD28 mediated upregulation of glucose metabolism and Akt activity, but each accomplished this regulation using separate mechanisms ... In contrast, PD-1 signaling inhibits Akt phosphorylation by preventing CD28 mediated activation of phosphatidylinositol 3-kinase (PI3K)
Perchonock et al., Mol Cell Biol 2006 (Splenomegaly) : While TCR/CD28 mediated activations of phosphotyrosine induction, extracellular signal regulated kinase 1/2, Jun N-terminal protein kinase, IkappaB kinase alpha/beta, and Akt were unaltered, constitutive activation of p38 mitogen activated protein kinase and its upstream regulators MKK3/6 were observed for ALX-deficient splenocytes
Charvet et al., J Immunol 2006 : This defect was associated with impaired TCR/CD28 induced phosphorylation of Akt and the Forkhead family transcription factor, FOXO1
Pei et al., J Immunol 2008 : In vivo and in vitro data support a model in which CD28 costimulation activates AKT to phosphorylate NF90 at Ser647 and phosphorylation triggers NF90 to relocate to the cytoplasm and stabilize IL-2 mRNA
Dodson et al., Mol Cell Biol 2009 (Encephalomyelitis, Autoimmune, Experimental...) : Mutation of the proximal tyrosine motif interrupted PI3-kinase binding and prevented CD28 dependent phosphorylation of protein kinase B (PKB)/Akt ; however, there was no detectable effect on interleukin-2 (IL-2) secretion, expression of Bcl-X ( L ), or on T-cell function in vivo
Ordoñez-Rueda et al., Eur J Immunol 2009 : Interestingly, in response to CD3 plus CD28 costimulation, CD5 ( -/- ) naïve T cells but not CD5 ( -/- ) nTreg showed lower levels of p-Akt
Zhu et al., J Immunol 2010 : Our previous work showed that CD28 costimulation of T cells activated AKT to phosphorylate NF90 at Ser ( 647 ) and caused NF90 to undergo nuclear export and stabilize IL-2 mRNA